Neuropeptide Y receptors: a promising target for cancer imaging and therapy.
Neuropeptide Y receptors: a promising target for cancer imaging and therapy.
复制标题
神经肽 Y 受体：癌症成像和治疗的一个有前途的靶点。
DOI：
10.1093/rb/rbv013
复制
发表时间：
2015-09
影响因子：
6.7
通讯作者：
Wu A
中科院分区：
文献类型：
--
作者：
Li J;Tian Y;Wu A
神经肽Y（NPY）于1982年首次从猪脑中分离出来，并通过NPY受体（Y1、Y2、Y4和Y5）在人体中发挥其生物学功能。 NPY受体已知介导多种生理功能并参与大多数人类疾病，例如肥胖、高血压、癫痫和代谢紊乱。最近，人们发现NPY受体在许多癌症中过度表达，因此它们成为癌症诊断和治疗中有希望的靶点。本文重点介绍了NPY和NPY受体的最新研究成果，总结了目前关于NPY受体在癌症中的表达、NPY受体的选择性配体及其在癌症成像和治疗中的应用的认识。
Neuropeptide Y (NPY) was first identified from porcine brain in 1982, and plays its biological functions in humans through NPY receptors (Y1, Y2, Y4 and Y5). NPY receptors are known to mediate various physiological functions and involve in a majority of human diseases, such as obesity, hypertension, epilepsy and metabolic disorders. Recently, NPY receptors have been found to be overexpressed in many cancers, so they emerged as promising target in cancer diagnosis and therapy. This review focuses on the latest research about NPY and NPY receptors, and summarizes the current knowledge on NPY receptors expression in cancers, selective ligands for NPY receptors and their application in cancer imaging and therapy.