Interactions between microstructural and geometrical adaptation in human cortical bone
Interactions between microstructural and geometrical adaptation in human cortical bone
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DOI：
10.1002/jor.20159
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发表时间：
2006-07-01
影响因子：
2.8
通讯作者：
Vashishth, Deepak
中科院分区：
文献类型：
--
作者：
Ural, Ani;Vashishth, Deepak
随着年龄的增长和疾病的发展，骨的微观结构和几何结构的变化会影响皮质骨的力学性能，但两者之间的相互作用程度尚不清楚。在这里，我们调查了衰老的男性胫骨中段近端和远端的微观结构和几何性质的变化之间的相互作用。显微结构测量包括与骨小球的大小和密度以及皮质内孔隙率相关的变量。宏观几何属性包括与骨表面(骨膜和骨内膜)和横截面(面积、转动惯量)相关的变量。沿骨骼长度和不同骨表面的显微结构和几何特性之间存在特定部位的相关性。与不存在相关性的男性胫骨中段近端相比，胫骨中段远端存在显著的相关性。部分与皮质骨形成有关的参数的变化，包括骨化面积，与骨膜直径的增加呈正相关。类似地，与骨吸收和/或皮质形成失败相关的参数，包括孔隙率和孔径大小，与皮质变薄显示出显著的相关性。这些发现支持这样的概念，随着年龄的增长，人类胫骨在微观结构和宏观结构水平上的合成代谢和分解代谢反应具有空间相关性和位置特异性。(C)2006年骨科研究会。由威利期刊出版公司出版。
With aging and in disease, the changes in bone microstructure and geometry influence the mechanical properties of cortical bone, however, the level of interaction between the two is not known. Here, we investigate the interaction between the changes in microstructural and geometrical properties of the aging male tibia in proximal and distal middiaphysis. The microstructural measurements include variables related to the size and density of osteons and intracortical porosity. The macroscopic geometrical properties include variables related to bone surfaces (periosteal and endosteal) and cross section (area, moment of inertia). Site-specific correlations were found between the microstructural and geometrical properties along the bone length and at different bone surfaces. In contrast to the proximal middiaphysis of male tibia, where no correlation existed, significant p < 0.05) correlations were found in the distal middiaphysis of tibia. The changes in parameters partially related to bone formation in the cortex, including the osteonal area, showed positive correlations with an increase in the periosteal diameter. Similarly, parameters related to bone resorption and/or failed formation in the cortex, including porosity and pore size, showed significant correlations with cortical thinning. These findings support the concept that, with aging, anabolic and catabolic responses in the human tibia at microstructural and macrostructural levels are spatially related and site specific. (c) 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.