Advances in Biodistribution Study and Tracing Methodology of Carbon Nanotubes
Advances in Biodistribution Study and Tracing Methodology of Carbon Nanotubes
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碳纳米管生物分布研究及示踪方法的进展
DOI：
10.1166/jnn.2010.2689
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发表时间：
2010-12-01
影响因子：
--
通讯作者：
Liu, Yuanfang
中科院分区：
文献类型：
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作者：
Liu, Jia-Hui;Yang, Sheng-Tao;Liu, Yuanfang
碳纳米管（CNTs）的最新应用进展需要对其在体内的行为和命运进行深入的研究。生物分布作为药理学和毒理学的基础信息，应深入系统地研究，加快相关研究。在这篇综述中，我们总结了目前应用于碳纳米管生物分布研究的方法和已获得的生物分布数据。然而，目前使用的方法，包括同位素标记、拉曼光谱和透射电镜研究，很难达到方便性和可靠性的完美平衡。我们比较了每种方法的优点和缺点，以显示不同目的的多样化选择。基于这些技术，现有数据表明碳纳米管具有网状内皮系统（RES）高摄取的总体趋势。但是它们的分布可以通过碳纳米管表面的各种分子的功能化而显著地调节。对于未来的生物分布研究，迫切需要开发方便可靠的方法，并进一步探索和揭示决定CNTs在体内行为和命运的关键参数。
Recent advances in applications of carbon nanotubes (CNTs) require thorough investigation of their in vivo behavior and fate. Biodistribution, as fundamental information for pharmacology and toxicology, should be intensively and systematically studied to accelerate the related researches. In this review, we summarized currently applied methodology in the study of CNTs biodistribution and the achieved biodistribution data. However, the currently used methods, including isotopic labeling, Raman spectroscopy and TEM investigation, can hardly reach a perfect balance of convenience and reliability. We compared the advantage and disadvantage of each method to show diversified choices for different purposes. Based on these techniques, available data suggest that CNTs have a general trend of high reticuloendothelial system (RES) uptake. But their distribution can be dramatically regulated by functionalization of the CNT surface with various molecules. For future biodistribution studies, developing convenient and reliable methods is highly required, and key parameters determining the behavior and fate of CNTs in vivo should be further explored and elicited.