The role of the dorsal anterior insula in sexual risk: Evidence from an erotic Go/NoGo task and real-world risk-taking.
The role of the dorsal anterior insula in sexual risk: Evidence from an erotic Go/NoGo task and real-world risk-taking.
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背侧前岛叶在性风险中的作用：来自色情 Go/NoGo 任务和现实世界冒险的证据。
DOI：
10.1002/hbm.23931
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发表时间：
2018
影响因子：
4.8
通讯作者：
Read,StephenJ
中科院分区：
文献类型：
--
作者：
Xue,Feng;Droutman,Vita;Barkley-Levenson,EmilyE;Smith,BenjaminJ;Xue,Gui;Miller,LynnC;Bechara,Antoine;Lu,Zhong-Lin;Read,StephenJ
在反应抑制中起重要作用。最相关的是，有人提出，背侧前岛叶皮层（dAIC）在负责默认模式网络和执行控制网络之间切换的显着性网络中起着核心作用。然而，在性动机的反应抑制中的作用还没有被研究。在这项研究中，85名18至30岁的性活跃男性与男性发生性关系（MSM）在MRI扫描仪中执行色情Go/NoGo任务。参与者的真实的性冒险（过去90天内无避孕套肛交的频率）与他们在任务期间的神经活动相关。我们发现，在具有更强动机信息的对比（有吸引力的裸体男性照片与穿着衣服的中年女性照片）和需要更大反应抑制的对比（NoGo与Go）中，双侧前岛叶皮层（背侧和腹侧）的活动更大。我们还发现，右侧dAIC的活动与参与者的真实的性冒险行为呈负相关。我们的研究结果证实了岛叶皮层参与动机性反应抑制。特别是，当个体面临需要抑制性控制的情况时，右侧dAIC活动的减少可能会降低执行控制网络上线的可能性，从而导致他们做出更危险的选择。
The insula plays an important role in response inhibition. Most relevant here, it has been proposed that the dorsal anterior insular cortex (dAIC) plays a central role in a salience network that is responsible for switching between the default mode network and the executive control network. However, the insula's role in sexually motivated response inhibition has not yet been studied. In this study, eighty‐five 18‐ to 30‐year‐old sexually active men who have sex with men (MSM) performed an erotic Go/NoGo task while in an MRI scanner. Participants' real‐world sexual risk‐taking (frequency of condomless anal intercourse over the past 90 days) was then correlated with their neural activity during the task. We found greater activity in bilateral anterior insular cortex (both dorsal and ventral) on contrasts with stronger motivational information (attractive naked male pictures versus pictures of clothed, middle‐aged females) and on contrasts requiring greater response inhibition (NoGo versus Go). We also found that activity in the right dAIC was negatively correlated with participants' real‐world sexual risk‐taking. Our results confirmed the involvement of the insular cortex in motivated response inhibition. Especially, the decreased right dAIC activity may reduce the likelihood that the executive control network will come online when individuals are faced with situations requiring inhibitory control and thus lead them to make more risky choices.