Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness
Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness
复制标题
基于支柱[5]芳烃的超分子光敏剂可增强缺氧肿瘤的治疗效果
DOI：
10.1039/d1cc02959b
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发表时间：
2021-06-30
影响因子：
4.9
通讯作者：
Pei, Zhichao
中科院分区：
文献类型：
--
作者：
Chao, Shuang;Shen, Ziyan;Pei, Zhichao
基于主客体包合物构建了NBSPD的半乳糖靶向超分子光敏剂体系DOX@GP5超集。该超分子系统可实现DOX/NBS的高效递送和GSH刺激下的选择性释放。体外研究表明，这种超分子DOX/NBS共递送系统在低氧环境中表现出高的ROS产生和优异的癌细胞损伤能力。因此，这种策略可以通过化学-光动力学组合来实现增强的缺氧肿瘤治疗效果。
A galactose-targeting supramolecular photosensitizer system DOX@GP5 superset of NBSPD was constructed based on a host-guest inclusion complex. The supramolecular system could achieve efficient delivery of DOX/NBS and selective release under GSH stimulation. In vitro studies revealed that this supramolecular DOX/NBS co-delivery system exhibited high ROS production and excellent cancer cell damage capability in a hypoxic environment. This strategy can therefore achieve enhanced hypoxic-tumor therapeutic effectiveness by chemo-photodynamic combination.