Protein engineering strategies for the development of viral vaccines and immunotherapeutics.
Protein engineering strategies for the development of viral vaccines and immunotherapeutics.
复制标题
用于开发病毒疫苗和免疫疗法的蛋白质工程策略。
DOI：
10.1016/j.febslet.2013.10.014
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发表时间：
2014-01-21
期刊：
影响因子：
3.5
通讯作者：
Lai JR
中科院分区：
文献类型：
--
作者：
Koellhoffer JF;Higgins CD;Lai JR
Vaccines that elicit a protective broadly neutralizing antibody (bNAb) response and monoclonal antibody therapies are critical for the treatment and prevention of viral infections. However, isolation of protective neutralizing antibodies has been challenging for some viruses, notably those with high antigenic diversity or those that do not elicit a bNAb response in the course of natural infection. Here, we discuss recent work that employs protein engineering strategies to design immunogens that elicit bNAbs or engineer novel bNAbs. We highlight the use of rational, computational, and combinatorial strategies and assess the potential of these approaches for the development of new vaccines and immunotherapeutics.
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DOI：
10.1073/pnas.0812952106
发表时间：
2009-03-03
影响因子：
11.1
作者：
Gao, Junjun;Sidhu, Sachdev S.;Wells, James A.
通讯作者：
Wells, James A.
影响因子：
6.4
作者：
Giles, Brendan M.;Crevar, Corey J.;Ross, Ted M.
通讯作者：
Ross, Ted M.
DOI：
10.1126/science.1175868
发表时间：
2009-11-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chen L;Kwon YD;Zhou T;Wu X;O'Dell S;Cavacini L;Hessell AJ;Pancera M;Tang M;Xu L;Yang ZY;Zhang MY;Arthos J;Burton DR;Dimitrov DS;Nabel GJ;Posner MR;Sodroski J;Wyatt R;Mascola JR;Kwong PD
通讯作者：
Kwong PD
DOI：
10.1126/science.1213782
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Diskin R;Scheid JF;Marcovecchio PM;West AP Jr;Klein F;Gao H;Gnanapragasam PN;Abadir A;Seaman MS;Nussenzweig MC;Bjorkman PJ
通讯作者：
Bjorkman PJ
影响因子：
5.4
作者：
Binley, James M.;Lybarger, Elizabeth A.;Mascola, John R.
通讯作者：
Mascola, John R.