Functional insights from studies on the structure of the nuclear pore and coat protein complexes.
Functional insights from studies on the structure of the nuclear pore and coat protein complexes.
复制标题
来自核孔和外壳蛋白复合物结构研究的功能见解。
DOI：
10.1101/cshperspect.a013375
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发表时间：
2013
影响因子：
7.2
通讯作者：
Schwartz,Thomas
中科院分区：
文献类型：
--
作者：
Schwartz,Thomas
核包膜（NE）是内质网（ER）的一种特殊延伸，包裹在细胞核周围，使基因转录和蛋白质翻译的空间分离成为可能，是真核生物的特征之一。NE的双脂质双分子层不是完全闭合的，而是在内外核膜融合的地方穿孔，形成圆形开口，内衬有急剧弯曲的膜。这些开口充满核孔复合物（npc），这是促进核运输的巨大蛋白质组合。鼻咽癌的支架成分与外壳蛋白复合物的元素惊人地具有有趣的相似性，这对这些膜涂层复合物的功能和进化具有一般意义。在这里，我将从结构的角度讨论这些发现可能教给我们的东西。
The nuclear envelope (NE) is a specific extension of the endoplasmic reticulum (ER) that wraps around the nucleus and enables the spatial separation of gene transcription and protein translation, one of the signature features of eukaryotes. Rather than being completely closed, the double lipid bilayer of the NE is perforated at sites where the inner and outer nuclear membranes fuse, resulting in circular openings lined with sharply bent membranes. These openings are filled with nuclear pore complexes (NPCs), enormous protein assemblies that facilitate nuclear transport. The scaffold components of the NPC surprisingly share interesting similarities with elements of coat protein complexes, which have general implications for function and evolution of these membrane-coating complexes. Here I discuss, from a structural perspective, what these findings might teach us.