Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells.
Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells.
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DOI：
10.1155/2015/264502
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发表时间：
2015
影响因子：
4.6
通讯作者：
Zhu J
中科院分区：
文献类型：
--
作者：
Zhong C;Zhu J
最近对先天淋巴样细胞(ILCs)的研究扩大了我们对免疫系统先天手臂的了解。辅助性ILC既具有传统自然杀伤(CNK)细胞的“先天”特性，又具有CD4+T辅助(Th)细胞的“辅助性”特性。在这种结合下，辅助性ILC能够启动类似于CNK细胞的早期免疫反应，但通过分泌一系列类似于Th细胞产生的效应细胞因子。虽然许多研究已经揭示了辅助性ILCs和Th细胞之间的功能相似性，但ILCs的某些方面，包括这一谱系的发展，仍然难以捉摸。有趣的是，大多数转录因子参与T细胞发育、分化和功能的多个阶段，也在ILC的发展过程中发挥关键作用。Id2、GATA-3、Nfil3、TOX和TCF-1等调节因子在ILC发育的不同阶段都有表达和功能。在本文中，我们将对ILCs和Th细胞共有的这些转录因子的表达和功能进行综述。我们还将为ILC的谱系承诺提出一个复杂的转录调控网络。
Recent studies on innate lymphoid cells (ILCs) have expanded our knowledge about the innate arm of the immune system. Helper-like ILCs share both the “innate” feature of conventional natural killer (cNK) cells and the “helper” feature of CD4+ T helper (Th) cells. With this combination, helper-like ILCs are capable of initiating early immune responses similar to cNK cells, but via secretion of a set of effector cytokines similar to those produced by Th cells. Although many studies have revealed the functional similarity between helper-like ILCs and Th cells, some aspects of ILCs including the development of this lineage remain elusive. It is intriguing that the majority of transcription factors involved in multiple stages of T cell development, differentiation, and function also play critical roles during ILC development. Regulators such as Id2, GATA-3, Nfil3, TOX, and TCF-1 are expressed and function at various stages of ILC development. In this review, we will summarize the expression and functions of these transcription factors shared by ILCs and Th cells. We will also propose a complex transcriptional regulatory network for the lineage commitment of ILCs.