CHILDHOOD ECZEMA - DISEASE OF THE ADVANTAGED
CHILDHOOD ECZEMA - DISEASE OF THE ADVANTAGED
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DOI：
10.1136/bmj.308.6937.1132
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发表时间：
1994-04-30
影响因子：
--
通讯作者：
HAY, RJ
中科院分区：
文献类型：
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作者：
WILLIAMS, HC;STRACHAN, DP;HAY, RJ
目的 - 确定在社会经济优势群体中儿童湿疹患病率增加是否是由于父母报告增加所致。
设计 - 将父母报告的湿疹情况与医务人员在详细体格检查期间记录的可见湿疹情况进行比较。
研究背景 - 全国出生队列研究。
研究对象 - 1958年3月3日至9日出生于英格兰、威尔士和苏格兰的8279名儿童，并在7岁、11岁和16岁时进行随访。
主要观察指标 - 根据父母报告的湿疹患病率与医务人员在7岁、11岁和16岁时检查的结果进行比较。
结果 - 在7岁、11岁和16岁时，报告的和经检查的湿疹患病率均随社会阶层升高而增加。7岁时经检查的湿疹时点患病率在社会阶层Ⅰ、Ⅱ、Ⅲ非体力劳动者、Ⅲ体力劳动者、Ⅳ和Ⅴ中分别为4.8%、3.6%、3.6%、2.4%、2.2%和2.4%（线性趋势的卡方值为12.6，P < 0.001）。在对地区和家庭规模等潜在混杂因素进行调整后，这种趋势仍然存在，而对于经检查的银屑病或痤疮则不存在这种趋势。
结论 - 在英国学龄儿童中，社会阶层Ⅰ和Ⅱ的儿童湿疹患病率高于较低阶层的儿童。与社会阶层相关的暴露因素在儿童湿疹的发生中可能至少与遗传因素同样重要。
Objective-To determine whether the increased prevalence of childhood eczema in advantaged socioeconomic groups is due to increased parental reporting.Design-Comparison of parental reports of eczema with visible eczema recorded by medical officers during a detailed physical examination.Setting-National birth cohort study.Subjects-8279 children from England, Wales, and Scotland born during 3-9 March 1958 and followed up at the ages of 7, 11, and 16.Main outcome measures-Prevalence of eczema according to parental report compared with medical officer's examination at the ages of 7, 11, and 16.Results-Prevalence of both reported and examined eczema increased with rising social class at the ages of 7, 11, and 16 years. The point prevalence of examined eczema at age 7 was 4.8%, 3.6%, 3.6%, 2.4%, 2.2%, and 2.4% in social classes I, II, III nonmanual, III manual, TV, and V respectively (chi(2) value for linear trend 12.6, P < 0.001). This trend persisted after adjustment for potential confounders such as region and family size and was not present for examined psoriasis or acne.Conclusions-Eczema is more prevalent among British schoolchildren in social classes I and II than those in lower classes, Exposures associated with social class are probably at least as important as genetic factors in the expression of childhood eczema.