Reproductive functions of the progesterone receptor
Reproductive functions of the progesterone receptor
复制标题
DOI：
10.1016/s1071-5576(99)00062-3
复制
发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
O'Malley, BW
中科院分区：
文献类型：
--
作者：
Conneely, OM;Lydon, JP;O'Malley, BW
孕激素在调节与妊娠的建立和维持相关的生殖事件中起中心协调作用，包括排卵、子宫和乳腺发育和肿瘤发生以及与性反应相关的神经行为表达。孕酮的作用由两种受体蛋白（PR）介导，称为A和B，它们来自单个基因，并作为配体激活的转录因子调节生殖靶基因的表达。这两种蛋白质在小鼠中的突变导致多效性生殖异常。本文综述了PR亚型的结构和功能特性，以及这些蛋白质之间的功能差异可能会影响受体在生殖系统中的整体生理作用。（J Soc Gynecol Investig 2000;7：S25-32）版权所有（C）2000，妇科研究学会。
Progesterone plays a central coordinate role in regulating reproductive events associated with the establishment and maintenance of pregnancy including ovulation, uterine and mammary gland development and tumorigenesis, and neurobehavioral expression associated with sexual responsiveness. The effects of progesterone are mediated by two receptor proteins (PR), termed A and B, that arise from a single gene and act as ligand-activated transcription factors to regulate the expression of reproductive target genes. Null mutation of both proteins in mice leads to pleiotropic reproductive abnormalities. This review summarizes the structure and functional properties of the PR isoforms and how functional differences between these proteins are likely to impact on the overall physiologic role of the receptor in reproductive systems. (J Soc Gynecol Investig 2000;7:S25-32) Copyright (C) 2000 by the Society for Gynecologic Investigation.