Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis
Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis
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DOI：
10.1002/jmv.25735
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发表时间：
2020-06-01
影响因子：
12.7
通讯作者：
Xi, Jianing
中科院分区：
文献类型：
--
作者：
Sun, Pengfei;Qie, Shuyan;Xi, Jianing
目的通过对已发表的关于严重急性呼吸综合征冠状病毒2型（SARS CoV-2）患者临床特征的研究进行分析，总结SARS CoV-2治疗和预防的循证医学证据。结果共纳入10篇研究，共纳入50 466例SARS-CoV-2感染患者。Meta分析显示，在这些患者中，发热的发生率为0.891（95%CI：0.818，0.945），咳嗽的发生率为0.722（95%CI：0.657，0.782），肌肉酸痛或疲劳的发生率为0.425（95%CI：0.213，0.652）。急性呼吸窘迫综合征（ARDS）发生率为0.148（95%CI：0.046，0.296），胸部CT异常发生率为0.966（95%CI：0.921，0.993），重症病例占全部感染病例的百分比为0.181（95%CI：0.127，0.243），SARS-CoV-2感染患者病死率为0.043结论SARS-CoV-2感染者最常见的临床症状为发热和咳嗽，且多数患者胸部CT检查异常。有些人有肌肉酸痛或疲劳以及ARDS。腹泻、咯血、头痛、咽痛、休克等症状少见。SARS-CoV-2感染患者的病死率低于严重急性呼吸综合征（SARS）和中东呼吸综合征（MERS）。本荟萃分析也存在局限性，因此本荟萃分析的结论仍需要更多设计更细致、执行更严格、样本量更大的相关研究进行验证。
Objective We aim to summarize reliable evidence of evidence-based medicine for the treatment and prevention of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by analyzing all the published studies on the clinical characteristics of patients with SARS-CoV-2.Methods PubMed, Cochrane Library, Embase, and other databases were searched. Several studies on the clinical characteristics of SARS-CoV-2 infection were collected for meta-analysis.Results Ten studies were included in Meta-analysis, including a total number of 50466 patients with SARS-CoV-2 infection. Meta-analysis shows that, among these patients, the incidence of fever was 0.891 (95% CI: 0.818, 0.945), the incidence of cough was 0.722 (95% CI: 0.657, 0.782), and the incidence of muscle soreness or fatigue was 0.425 (95% CI: 0.213, 0.652). The incidence of acute respiratory distress syndrome (ARDS) was 0.148 (95% CI: 0.046, 0.296), the incidence of abnormal chest computer tomography (CT) was 0.966 (95% CI: 0.921, 0.993), the percentage of severe cases in all infected cases was 0.181 (95% CI: 0.127, 0.243), and the case fatality rate of patients with SARS-CoV-2 infection was 0.043 (95% CI: 0.027, 0.061).Conclusion Fever and cough are the most common symptoms in patients with SARS-CoV-2 infection, and most of these patients have abnormal chest CT examination. Several people have muscle soreness or fatigue as well as ARDS. Diarrhea, hemoptysis, headache, sore throat, shock, and other symptoms are rare. The case fatality rate of patients with SARS-CoV-2 infection is lower than that of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). This meta-analysis also has limitations, so the conclusions of this Meta-analysis still need to be verified by more relevant studies with more careful design, more rigorous execution, and larger sample size.