Multiple pregnancy as a potential risk factor for postpartum depression: The Japan Environment and Children's Study
Multiple pregnancy as a potential risk factor for postpartum depression: The Japan Environment and Children's Study
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多胎妊娠是产后抑郁症的潜在危险因素：日本环境与儿童研究
DOI：
10.1016/j.jad.2023.02.088
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发表时间：
2023
影响因子：
6.6
通讯作者：
Yamagata Zentaro
中科院分区：
文献类型：
--
作者：
Shinohara Satoshi;Horiuchi Sayaka;Shinohara Ryoji;Otawa Sanae;Kushima Megumi;Miyake Kunio;Yui Hideki;Kojima Reiji;Ooka Tadao;Akiyama Yuka;Yokomichi Hiroshi;Yamagata Zentaro
研究背景产后抑郁症（Postpartum depression，PPD）对母婴均造成不良后果。然而，多胎妊娠与PPD之间的关联尚不清楚，因为基于国家、种族和研究类型的PPD估计患病率存在差异。因此，本研究旨在确定日本妇女多胎妊娠是否在产后1个月和6个月患PPD的高风险。MethodsIn这个全国性的前瞻性队列研究（日本环境与儿童研究），在2011年1月至2014年3月进行，77,419名孕妇参加。产后1个月和6个月使用爱丁堡产后抑郁量表（EPDS）评估PPD。评分≥13分意味着PPD“阳性”。多元Logistic回归分析估计多胎妊娠和PPD risk.ResultsOverall之间的关联，77,419怀孕（单胎，n= 76,738;双胞胎，n= 676;三胞胎，n= 5）包括; 3.6%和2.9%的孕妇产后1个月和6个月的PPD，分别。与单胎妊娠相比，多胎妊娠产后1个月时PPD发生率无显著性差异，产后6个月时PPD发生率无显著性差异（调整后的奇数比：分别为0.968 [95%置信区间{CI}，0.633-1.481]和1.554 [95% CI，1.046-2.308]。局限性1）一些潜在的PPD风险因素无法评估，2）PPD没有诊断精神科医生，和3）产后6个月的抑郁症状被认为是PPD，但是，定义可能会有所不同.ConclusionsJapanese妇女多胎妊娠可被视为一个目标群体的后续行动和产后抑郁症筛查至少6个月在产后初期。
BackgroundPostpartum depression (PPD) results in adverse consequences for both mother and infant. However, the association between multiple pregnancy and PPD is unknown because of the difference in the estimated prevalence rate of PPD based on country, ethnicity, and study type. Thus, this study aimed to determine whether Japanese women with multiple pregnancy were at a high risk of developing PPD at 1 and 6 months postpartum.MethodsIn this nationwide prospective cohort study (the Japan Environment and Children's Study), conducted between January 2011 and March 2014, 77,419 pregnant women were enrolled. PPD was assessed using the Edinburgh Postnatal Depression Scale (EPDS) 1 and 6 months postpartum. A score of ≥13 points implied “positive” for PPD. Multiple logistic regression analyses estimated the association between multiple pregnancy and PPD risk.ResultsOverall, 77,419 pregnancies (singleton,n= 76,738; twins,n= 676; triplets,n= 5) were included; 3.6 % and 2.9 % of pregnant women had PPD at 1 and 6 months postpartum, respectively. Compared with singleton pregnancy, multiple pregnancy was not associated with PPD at 1 month, but at 6 months postpartum (adjusted odd ratios: 0.968 [95 % confidence interval {CI}, 0.633–1.481] and 1.554 [95 % CI, 1.046–2.308], respectively).Limitations1) Some potential PPD risk factors could not be evaluated, 2) PPD was not diagnosed by psychiatrists, and 3) depressive symptoms at 6 months postpartum were considered PPD; however, definitions may vary.ConclusionsJapanese women with multiple pregnancy may be regarded as a target group for follow-up and postpartum depression screening for at least 6 months during the initial postpartum period.