Epidemiology of osteoarthritis: literature update.
Epidemiology of osteoarthritis: literature update.
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DOI：
10.1097/bor.0000000000000479
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发表时间：
2018-03
影响因子：
5.1
通讯作者：
Kwoh CK
中科院分区：
文献类型：
--
作者：
Vina ER;Kwoh CK
这篇综述的目的是强调骨关节炎流行病学的最新研究，包括患病率、疾病影响和潜在危险因素的研究。骨关节炎（OA）在美国和全球各地非常普遍。地球仪。它是导致残疾的主要原因，并可能对人们的身心健康产生负面影响。与管理疾病相关的医疗保健资源和成本可能是巨大的。越来越多的证据表明，不同的OA表型反映了疾病的不同机制。认识到各种个人层面的风险因素，包括社会人口特征（例如，女性，非裔美国人种族）、遗传倾向、肥胖、饮食相关因素和高骨密度/骨质量。关节水平的风险因素包括特定的骨/关节形状、大腿屈肌无力、关节排列不良、参与某些职业/体育活动和关节损伤。最近的研究提高了我们对OA相关的影像学前病变的认识。这些新发现的应用可能使我们能够开发创新的策略和新的治疗方法，以预防新的疾病发作并最大限度地减少疾病进展。
The purpose of this review is to highlight recent studies of osteoarthritis epidemiology, including research on prevalence, disease impact, and potential risk factors. Osteoarthritis (OA) is highly prevalent in the US and around the globe. It is a leading cause of disability and can negatively impact people’s physical and mental well-being. Healthcare resources and costs associated with managing the disease can be substantial. There is increasing evidence that there are different OA phenotypes that reflect different mechanisms of the disease. Various person-level risk factors are recognized, including sociodemographic characteristics (e.g., female gender, African-American race), genetic predispositions, obesity, diet-related factors, and high bone density/mass. Joint-level risk factors include specific bone/joint shapes, thigh flexor muscle weakness, joint malalignment, participation in certain occupational/sports activities, and joint injury. Recent studies have enhanced our understanding of pre-radiographic lesions associated with OA. Application of these new findings may allow us to develop innovative strategies and novel therapies with the purpose of preventing new disease onset and minimizing disease progression.