Materials based tumor immunotherapy vaccines.
Materials based tumor immunotherapy vaccines.
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DOI：
10.1016/j.coi.2012.12.008
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发表时间：
2013-04
影响因子：
7
通讯作者：
Mooney DJ
中科院分区：
文献类型：
--
作者：
Li WA;Mooney DJ
免疫疗法是治疗癌症的一种有前途的方法。然而，有固有的局限性，目前的方法，这可能会解决整合它们与生物材料为基础的战略。已经制造了材料平台以通过免疫调节剂的空间和时间控制的递送与免疫细胞相互作用并促进免疫细胞串扰。已经开发了颗粒疫苗以特异性地靶向和递送药剂至器官、细胞和亚细胞区室。这些策略已显示产生抗原特异性CTL应答，并且在某些情况下产生肿瘤消退。因此，免疫学和材料工程学之间的合作可能会导致在未来创建强大的疫苗来对抗癌症。
Immunotherapy is a promising approach for treating cancer. However, there are limitations inherent to current approaches which may be addressed by integrating them with biomaterial-based strategies. Material platforms have been fabricated to interact with immune cells through spatially- and temporally-controlled delivery of immune modulators and to promote immune cell crosstalk. Particle vaccines have been developed to specifically target and deliver agents to organs, cells and subcellular compartments. These strategies have been shown to generate antigen-specific CTL responses and, in some cases, tumor regression. Therefore, collaboration between immunology and materials engineering is likely to result in the creation of strong vaccines to combat cancer in the future.
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影响因子：
6.2
作者：
Hu, Yuhua;Atukorale, Prabhani U.;Lu, James J.;Moon, James J.;Um, Soong Ho;Cho, Eun Chol;Wang, Yana;Chen, Jianzhu;Irvine, Darrell J.
通讯作者：
Irvine, Darrell J.
DOI：
10.1073/pnas.1112648109
发表时间：
2012-01-24
影响因子：
11.1
作者：
Moon, James J.;Suh, Heikyung;Irvine, Darrell J.
通讯作者：
Irvine, Darrell J.
影响因子：
3.7
作者：
Ali, Omar A.;Doherty, Ed;Emerich, Dwaine F.
通讯作者：
Emerich, Dwaine F.
影响因子：
14
作者：
Hori, Yuki;Winans, Amy M.;Irvine, Darrell J.
通讯作者：
Irvine, Darrell J.
DOI：
10.1073/pnas.1105200108
发表时间：
2011-09-20
影响因子：
11.1
作者：
Jewell, Christopher M.;Lopez, Sandra C. Bustamante;Irvine, Darrell J.
通讯作者：
Irvine, Darrell J.