Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: a HuGE review.
Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: a HuGE review.
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血管紧张素II类型1型受体多态性和对高血压的易感性：巨大的综述。
DOI：
10.1097/gim.0b013e3181809613
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发表时间：
2008-08
期刊：
影响因子：
--
通讯作者：
North KE
中科院分区：
文献类型：
--
作者：
Mottl AK;Shoham DA;North KE
血管紧张素II 1型受体（AGTR 1）在血压控制中起着不可或缺的作用，并与高血压的发病机制有关。该基因内的多态性已被广泛研究与高血压;然而，结果是相互矛盾的。为了澄清这些数据，我们对AGTR 1多态性与高血压的关联研究进行了系统回顾，并对rs 5186变异进行了荟萃分析。结果表明，目前可用的文献太异质性，得出有意义的结论。高血压的定义和个体研究的性别构成有助于解释这种异质性。虽然AGTR 1的结构和剪接模式表明启动子区域内的多态性可能对基因功能产生影响，但迄今为止很少进行研究。总之，没有足够的证据表明AGTR 1基因多态性是高血压的危险因素。然而，大多数研究都没有足够的把握度，需要更大规模的设计良好的单倍型研究。
The angiotensin II type 1 receptor (AGTR1) plays an integral role in blood pressure control, and is implicated in the pathogenesis of hypertension. Polymorphisms within this gene have been extensively studied in association with hypertension; however, findings are conflicting. To clarify these data, we conducted a systematic review of association studies of AGTR1 polymorphisms and hypertension, and performed a meta-analysis of the rs5186 variant. Results show that the currently available literature is too heterogeneous to draw meaningful conclusions. The definition of hypertension and gender composition of individual studies helps to explain this heterogeneity. Although the structure and splicing pattern of AGTR1 would suggest a likely effect of polymorphisms within the promoter region on gene function, few studies have been conducted thus far. In conclusion, there is insufficient evidence that polymorphisms in the AGTR1 gene are risk factors for hypertension. However, most studies are inadequately powered, and larger well-designed studies of haplotypes are warranted.