Response to Bergmann et al: Carbon 14 Birth Dating of Human Cardiomyocytes.
Response to Bergmann et al: Carbon 14 Birth Dating of Human Cardiomyocytes.
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DOI：
10.1161/circresaha.111.259721
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发表时间：
2012-01-06
影响因子：
20.1
通讯作者：
Leri A
中科院分区：
文献类型：
--
作者：
Kajstura J;Rota M;Hosoda T;Anversa P;Leri A
伯格曼及其合作者在信中质疑了我们对他们关于人类心肌细胞随年龄增长的14C出生日期的研究的评论。他们提出了三点，试图挑战我们提出的问题，这些问题对他们关于心肌细胞更新与生理衰老的数据的有效性提出了严重的怀疑：(1)所检查的心肌样本的适当性；(2)分离心肌细胞核的方法的特异性；(3)正确解释14C测量值。
The letter by Bergmann and collaborators1 questions our comments2 regarding their work on 14C birth dating of human cardiomyocytes with aging. 3 Three points are made in an attempt to challenge the issues we have raised, which cast serious doubts on the validity of their data on myocyte turnover with physiological aging:(1) appropriateness of the myocardial samples examined;(2) specificity of the protocol used for the isolation of myocyte nuclei; and (3) correct interpretation of the 14C measurements.