Permethrin Alters Adipogenesis in 3T3-L1 Adipocytes and Causes Insulin Resistance in C2C12 Myotubes
Permethrin Alters Adipogenesis in 3T3-L1 Adipocytes and Causes Insulin Resistance in C2C12 Myotubes
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DOI：
10.1002/jbt.21580
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发表时间：
2014-09-01
影响因子：
3.6
通讯作者：
Park, Yeonhwa
中科院分区：
文献类型：
--
作者：
Kim, Jonggun;Park, Yooheon;Park, Yeonhwa
拟除虫菊酯是一类杀虫剂，其结构衍生自称为除虫菊酯的天然存在的杀虫剂。沿着新出现的证据表明，暴露于杀虫剂与体重增加和葡萄糖稳态改变有关，暴露于拟除虫菊酯与人体血糖水平改变有关。因此，本研究的目的是确定氯菊酯对脂质和葡萄糖代谢的作用。氯菊酯处理3 T3-L1脂肪细胞和C2 C12成肌细胞，以确定其在脂质和葡萄糖代谢中的作用，分别。氯菊酯处理导致脂肪细胞中脂肪生成和脂肪生成的关键标志物的表达增加。氯菊酯显着降低胰岛素刺激的葡萄糖摄取肌管。这是第一次报告的作用，氯菊酯改变脂肪细胞的脂质代谢和受损的葡萄糖稳态肌管。这些结果可能有助于阐明杀虫剂暴露（特别是氯菊酯）与肥胖及其合并症的潜在风险之间的基本潜在机制。(C)2014 Wiley Periodicals，Inc.
Pyrethroids are a class of insecticides structurally derived from the naturally occurring insecticides called pyrethrins. Along with emerging evidence that exposure to insecticides is linked to altered weight gain and glucose homeostasis, exposure to pyrethroids has been linked to altered blood glucose levels in humans. Thus, the purpose of this study was to determine the role of permethrin on lipid and glucose metabolisms. Permethrin was treated to 3T3-L1 adipocytes and C2C12 myoblasts to determine its role in lipid and glucose metabolisms, respectively. Permethrin treatment resulted in increased expression of key markers of adipogenesis and lipogenesis in adipocytes. Permethrin significantly reduced insulin-stimulated glucose uptake in myotubes. This is the first report on the role of permethrin in altered lipid metabolism in adipocytes and impaired glucose homeostasis in myotubes. These results may help elucidate fundamental underlying mechanisms between insecticide exposure, particularly permethrin, and potential risk of developing obesity and its comorbidities. (C) 2014 Wiley Periodicals, Inc.