Clinical value of the malnutrition-inflammation-atherosclerosis syndrome for long-term prediction of cardiovascular mortality in patients with end-stage renal disease: A 5-year prospective study
Clinical value of the malnutrition-inflammation-atherosclerosis syndrome for long-term prediction of cardiovascular mortality in patients with end-stage renal disease: A 5-year prospective study
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DOI：
10.1159/000113526
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Gullulu, Mustafa
中科院分区：
文献类型：
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作者：
Akdag, Ibrahim;Yilmaz, Yusuf;Gullulu, Mustafa
背景/目的：终末期肾病（ESRD）患者心血管疾病导致的死亡率较高。在这项研究中，我们试图调查营养不良-炎症-动脉粥样硬化（MIA）综合征的临床价值，长期预测心血管死亡率的患者治疗终末期肾病。方法：共纳入42例接受血液透析的ESRD患者。测定炎症标志物和营养参数。通过超声评价颈动脉内膜中层厚度（cIMT）来研究颈动脉粥样硬化。在5年随访时评价死亡率。结果：营养指标与炎症指标无明显相关性。cIMT与透析前血清白蛋白呈负相关。在42例患者的总体人群中，11例（26.2%）在随访期间死于心血管原因。Kaplan-Meier生存曲线显示cIMT（>= 0.9 mm）、C反应蛋白（CRP）（>1 mg/dl）和血清白蛋白（
Background/Aim: Mortality resulting from cardiovascular disease in patients with end-stage renal disease (ESRD) is high. In this study we sought to investigate the clinical value of the malnutrition-inflammation-atherosclerosis (MIA) syndrome for long-term prediction of cardiovascular mortality in patients treated with ESRD. Methods: A total of 42 ESRD patients on hemodialysis were enrolled. Inflammatory markers and nutritional parameters were determined. Carotid atherosclerosis was investigated by ultrasonographically evaluated carotid intima-media thickness (cIMT). Mortality was evaluated at a 5-year follow-up. Results: No correlation was evident between nutritional markers and inflammatory indexes. cIMT was inversely correlated with predialysis serum albumin. In the overall population of 42 patients, 11 (26.2%) died of cardiovascular causes during follow-up. Kaplan-Meier survival curves indicate that cIMT (>= 0.9 mm), C-reactive protein (CRP) (>1 mg/dl), and serum albumin (