A novel method for calculating mean erythrocyte age using erythrocyte creatine
A novel method for calculating mean erythrocyte age using erythrocyte creatine
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DOI：
10.18632/aging.103193
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发表时间：
2020-05-15
期刊：
影响因子：
5.2
通讯作者：
Okumiya, Toshika
中科院分区：
文献类型：
--
作者：
Kameyama, Masashi;Koga, Masafumi;Okumiya, Toshika
估计红细胞寿命有助于贫血的鉴别诊断。然而，测量红细胞的寿命非常困难;因此，很少测量。红细胞肌酸（EC）减少反映红细胞年龄。我们建立了一种从EC中获得平均红细胞年龄（M-RBC）的方法，并重新分析了21例溶血性贫血患者的EC和Cr-51的半衰期。M-RBC和log（e）EC具有良好的线性关系（r =-0.9475，p < 0.001），证明在所研究的范围内（EC：1.45 - 11.76 μ mol/g Hb），它可以被视为单指数关系。建立了由EC（μ mol/gHb）计算M-RBC（天）的方程：M-RBC = -22.84log（e）EC +65.83。
Estimating the lifespan of erythrocytes is useful for the differential diagnosis of anemia. However, measuring the lifespan of erythrocytes was very difficult; therefore, it was seldom measured. Erythrocyte creatine (EC) decreases reflecting erythrocyte age. We developed a method to obtain mean erythrocyte age (M-RBC) from EC.We reanalyzed the previously published data from 21 patients with hemolytic anemia, which included EC and the half-life of Cr-51.M-RBC and log(e) EC showed excellent significant linearity (r = -0.9475, p < 0.001), proving that it could be treated as a mono-exponential relationship within the studied range (EC: 1.45 - 11.76 mu mol/g Hb). We established an equation to obtain M-RBC (days) from EC (mu mol/g Hb): M-RBC = -22.84log(e) EC + 65.83.This equation allowed calculation of M-RBC based on EC which has practical applications such as the diagnosis of anemia.