Monoclonal antibody-based optical molecular imaging probes; considerations and caveats in chemistry, biology and pharmacology.
Monoclonal antibody-based optical molecular imaging probes; considerations and caveats in chemistry, biology and pharmacology.
复制标题
DOI：
10.1016/j.cbpa.2016.05.015
复制
发表时间：
2016-08
影响因子：
7.8
通讯作者：
Ogawa, Mikako
中科院分区：
文献类型：
--
作者：
Kobayashi, Hisataka;Choyke, Peter L.;Ogawa, Mikako
单克隆抗体（mAb）具有上级特异性，是设计特异性分子成像探针的良好平台。已经开发了几种光学成像探头用于患者的手术导航，并处于早期临床试验阶段。然而，使用mAb的固有限制是其药代动力学，其导致循环半衰期延长和从体内清除缓慢。这导致成像期间不期望的目标与背景比。本文首先介绍了单克隆抗体作为光学探针设计的平台材料，然后从化学、生物学和药理学三个方面讨论了基于单克隆抗体的光学分子成像探针的优化设计。
The monoclonal antibody (mAb) has proven to be a good platform for designing specific molecular imaging probes due to its superior binding specificity. Several optical imaging probes have been developed for surgical navigation in patients and are in early phase clinical trials. However, an inherent limitation of using the mAb is its pharmacokinetics which result in a prolonged circulating half-life and slow clearance from the body. This results in undesirable target to background ratios during imaging. In this review, we first describe the mAb as a platform material for optical probe design and then discuss optimizing the design of monoclonal antibody-based optical molecular imaging probes by focusing on chemistry, biology and pharmacology.
登录
查看更多内容
影响因子：
5.7
作者：
Ogawa M;Regino CA;Choyke PL;Kobayashi H
通讯作者：
Kobayashi H
影响因子：
62.1
作者：
Kobayashi, Hisataka;Ogawa, Mikako;Alford, Raphael;Choyke, Peter L.;Urano, Yasuteru
通讯作者：
Urano, Yasuteru
影响因子：
11.5
作者：
Barrett, Tristan;Koyama, Yoshinori;Kobayashi, Hisataka
通讯作者：
Kobayashi, Hisataka
影响因子：
5.7
作者：
Ferl, Gregory Z.;Kenanova, Vania;DiStefano, Joseph J., III
通讯作者：
DiStefano, Joseph J., III
影响因子：
5.8
作者：
KOBAYASHI, H;SAKAHARA, H;KONISHI, J
通讯作者：
KONISHI, J