Detection of BCR-ABL Positive Cells in an Asymptomatic Patient: A Case Report and Literature Review.
Detection of BCR-ABL Positive Cells in an Asymptomatic Patient: A Case Report and Literature Review.
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DOI：
10.1155/2010/939706
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发表时间：
2010
影响因子：
0.8
通讯作者：
Goodman M
中科院分区：
文献类型：
--
作者：
Bayraktar S;Goodman M
我们报告一例无症状的39岁男性患者，偶然发现其外周血白色细胞计数为15000/mm 3，并通过FISH和RT-PCR在51/300的细胞中检测到阳性BCR-ABL/t（9;22）（q34;q11）染色体易位。在接下来的3个月内，白细胞增多自发消退;然而，通过RT-PCR和FISH检测的BCR-ABL在外周血和骨髓中持续存在。患者未开始任何治疗，并定期进行实验室检查和体格检查，以监测慢性粒细胞白血病（CML）的体征和症状以及BCR-ABL转录本的生物学行为。监测1年时，患者无疾病;但持续检测到BCR-ABL融合基因。我们的病例具有挑战性，因为BCR-ABL阳性的健康无症状患者发生CML的实际风险尚不清楚。
We report a case of an asymptomatic 39-year-old male who was incidentally found to have a white blood cell count of 15 000/mm3 associated with a positive BCR-ABL/t(9;22)(q34;q11) chromosomal translocation detected in 51/300 of cells by FISH and RT-PCR from peripheral blood. Within the next 3 months, leukocytosis spontaneously subsided; however, BCR-ABL by RT-PCR and FISH was persistent both in peripheral blood and bone marrow. The patient was not started on any therapy and is being followed regularly with laboratory checkup and physical examination for monitoring signs and symptoms of chronic myeloid leukemia (CML) and biological behavior of his BCR-ABL transcripts. At 1 year of surveillance, he is disease free; however he has persistent detection of BCR-ABL fusion gene. Our case is challenging because actual risk of developing CML in BCR-ABL positive healthy, asymptomatic patients is not known.