Highly Efficient Synthesis of a Class of Novel Chiral-Bridged Atropisomeric Monophosphine Ligands via Simple Desymmetrization and Their Applications in Asymmetric Suzuki-Miyaura Coupling Reaction
Highly Efficient Synthesis of a Class of Novel Chiral-Bridged Atropisomeric Monophosphine Ligands via Simple Desymmetrization and Their Applications in Asymmetric Suzuki-Miyaura Coupling Reaction
复制标题
通过简单去对称高效合成一类新型手性桥联阻转异构单膦配体及其在不对称铃木-宫浦偶联反应中的应用
DOI：
10.1021/ol300721p
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发表时间：
2012-04-20
期刊：
影响因子：
5.2
通讯作者：
Qiu, Liqin
中科院分区：
文献类型：
--
作者：
Wang, Shouliang;Li, Jinjin;Qiu, Liqin
通过简便的合成方法，合成了一系列新型手性桥联阻转异构单膦配体。所制备的配体，特别是配体7 d，被发现是非常有效的Pd催化Suzuki-Miyaura偶合反应。初步探讨了底物的空间位阻效应和电子效应对反应活性和对映选择性的影响。
A series of novel chiral-bridged atropisomeric monophosphine ligands were synthesized via convenient and simple pathways. The prepared ligands, especially for ligand 7d, were found to be highly effective in the Pd-catalyzed Suzuki-Miyaura coupling reaction. The steric hindrance and electronic effect of substrates on the reactivity and enantioselectivity were explored preliminarily.