A hydrochlorothiazide-imprinted polymer
A hydrochlorothiazide-imprinted polymer
复制标题
DOI：
10.1080/00032710008543090
复制
发表时间：
2000-01-01
影响因子：
2
通讯作者：
Tong, SY
中科院分区：
文献类型：
--
作者：
Chen, W;Liu, F;Tong, SY
Hydrochlorothiazide (HCT) is a medicine commonly used as a diuretic. A series of HCT-imprinted polymers were prepared using 4-vinylpyridine or methacrylic acid or none as a functional monomer. Liquid chromatographic analysis using the polymers as a stationary phase showed that 4-vinylpyridine was suitable for synthesizing HCT-selective polymers. It appeared that the sulfonamide groups on HCT molecule could interact with 4-vinylpyridine through ionic interaction, and thus could be used as a functional group for molecular imprinting. The prepared HCT-specific polymers should have applications for clinical analysis of HCT.
