Case-control studies of the efficacy of cancer screening: overcoming bias from nonrandom patterns of screening.
Case-control studies of the efficacy of cancer screening: overcoming bias from nonrandom patterns of screening.
复制标题
癌症筛查功效的病例对照研究：克服非随机筛查模式的偏差。
DOI：
10.1097/01.ede.0000129518.99816.e1
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Etzioni,Ruth
中科院分区：
文献类型：
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作者：
Weiss,NoelS;Dhillon,PreetK;Etzioni,Ruth
癌症筛查有效性的病例对照研究，像任何其他病例对照研究一样，必须处理潜在的混杂因素。有两类混杂变量对筛查研究造成特殊问题：（1）年龄和日历时间，这是由于病例和对照组之间筛查的时间分布不同而导致的，无论筛查试验是否导致死亡率降低;（2）当不清楚其他试验的结果是否与研究中的试验决定有关时，对所讨论的癌症进行其他筛查试验。我们描述了可以通过限制或调整令人满意地处理来自这些来源的混淆的情况，以及其他不能处理的情况。
A case-control study of the efficacy of cancer screening, like any other case-control study, must deal with potential confounding. There are 2 categories of confounding variables that pose special problems for studies of screening:(1) age and calendar time resulting from different temporal distributions of screening between cases and controls irrespective of whether the screening test leads to a reduction in mortality; and (2) the administration of other screening tests for the cancer in question when it is not clear whether the result of the other test had a bearing on the decision to order the test under study. We describe circumstances in which confounding from these sources can be dealt with satisfactorily by means of restriction or adjustment, and other circumstances in which it cannot.