Human IgG Fc-glycosylation profiling reveals associations with age, sex, female sex hormones and thyroid cancer
Human IgG Fc-glycosylation profiling reveals associations with age, sex, female sex hormones and thyroid cancer
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人类 IgG Fc 糖基化分析揭示了与年龄、性别、女性性激素和甲状腺癌的关联
DOI：
10.1016/j.jprot.2012.02.001
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发表时间：
2012-06-06
影响因子：
3.3
通讯作者：
Li, Zhili
中科院分区：
文献类型：
--
作者：
Chen, Guoqiang;Wang, Yanmin;Li, Zhili
免疫球蛋白的功能依赖于Fc区与其他蛋白质的相互作用，这些相互作用是通过剪裁ASN-297处保守的N-连接糖基化来优化的。我们进行了一项研究，涉及735名对照组和138名甲状腺癌患者。在这里，我们证明了先前描述的Fc糖基化与年龄相关的变化进一步表现为明确的性别特异性。在女性中，大多数糖化形式的发生率在青春期或更年期开始出现特征性变化。此外，在Fc糖基化中广泛存在着糖链-糖链关系，这种关系的特征是随着受试者的不同状态而改变，例如年龄、性别和甲状腺癌。在甲状腺癌患者中，将糖基化发生率与对照组进行详细比较，可以洞察到Ig G(1)Fc糖基化的异常变化。这种异常模式还具有显著的年龄和性别特异性。用受试者工作特征曲线分析确定Fc糖基化的诊断价值。最后，对两种主要的女性性激素雌二醇和孕酮进行了临床检测，以确定激素与Ig G Fc糖基化的潜在关联。本研究为探讨Ig G Fc N-连接糖基化与年龄、性别、女性性激素及甲状腺癌的关系提供了重要的观点。本文是题为：蛋白质组学：临床联系的特刊的一部分。(C)2012爱思唯尔B.V.保留所有权利。
IgG functions rely on interactions of the Fc region with other proteins, which are optimized by tailoring of a conserved N-linked glycosylation at Asn-297. We conducted a study involving 735 control individuals and 138 thyroid cancer patients. Here we demonstrated that previously described age-related change in Fc-glycosylation was further characterized by definite sex specificity. In females, the incidences of most of glycosylated forms began to pose characteristic changes at ages of puberty or menopause. In addition, glycan glycan relationships existed extensively within Fc glycosylation, which were characterized to be altered upon different states of subjects, such as age, sex and thyroid cancer. In thyroid cancer patients, detailed comparison of glycosylation incidences with control individuals yielded insight into aberrant change in IgG(1) Fc-glycosylation. This aberrant pattern was also featured by remarkable specificities of both age and sex. The receiver operating characteristic curve analysis was used to determine diagnostic values of Fc glycosylation. Finally, clinical measurement of two major female sex hormones estradiol and progesterone was conducted to determine potential associations of hormones with IgG Fc glycosylation. This study provided an important view to the associations of IgG Fc N-linked glycosylation with age, sex, female sex hormones and thyroid cancer. This article is part of a Special Issue entitled: Proteomics: The clinical link. (C) 2012 Elsevier B.V. All rights reserved.