Maternal Antibodies to Dietary Antigens and Risk for Nonaffective Psychosis in Offspring
Maternal Antibodies to Dietary Antigens and Risk for Nonaffective Psychosis in Offspring
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DOI：
10.1176/appi.ajp.2012.11081197
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发表时间：
2012-06-01
影响因子：
17.7
通讯作者：
Dalman, Christina
中科院分区：
文献类型：
--
作者：
Karlsson, Hakan;Blomstrom, Asa;Dalman, Christina
目的：作者分析了从新生儿获得的档案干血斑，以评估针对饮食抗原的免疫球蛋白G（IgG）水平是否与后来诊断的非情感性精神障碍相关。研究人群包括1975年至1985年在瑞典出生的个人，基于1987年至2003年之间的非情感性精神病诊断，并在性别、出生日期、出生医院和市政府方面进行比较。共有211例病例受试者和553例对照受试者同意参加本研究。与产妇状况、妊娠和分娩相关的因素数据来自瑞典医学出生登记。通过酶联免疫吸附测定法分析了干血斑洗脱液中针对麦醇溶蛋白（麸质的一种成分）和酪蛋白（牛奶蛋白）的IgG水平。结果：抗麦胶蛋白IgG（但不是抗酪蛋白IgG）水平高于第90百分位数的比较对象之间观察到的水平与非情感性精神病（比值比=1.7，95%CI =1.1-2.8）。这种关联并没有被母亲年龄、移民身份或分娩方式的差异所混淆。同样，出生时的胎龄，体重指数，出生体重与母体抗麦胶蛋白IgG水平无关。结论：高水平的抗麦胶蛋白IgG在母体循环中与后代的非情感性精神病的发展风险升高。需要进行研究，以确定这种关联的机制，以便制定预防战略。
Objective: The authors analyzed archival dried blood spots obtained from newborns to assess whether levels of immunoglobulin G (IgG) directed at dietary antigens were associated with a later diagnosis of a nonaffective psychotic disorder.Method: The study population consisted of individuals born in Sweden between 1975 and 1985 with verified register-based diagnoses of nonaffective psychoses made between 1987 and 2003 and comparison subjects matched on sex, date of birth, birth hospital, and municipality. A total of 211 case subjects and 553 comparison subjects consented to participate in the study. Data on factors associated with maternal status, pregnancy, and delivery were extracted from the Swedish Medical Birth Register. Levels of IgG directed at gliadin (a component of gluten) and casein (a milk protein) were analyzed in eluates from dried blood spots by enzyme-linked immunosorbent assay. Odds ratios were calculated for levels of IgG directed at gliadin or casein for nonaffective psychosis.Results: Levels of anti-gliadin IgG (but not anti-casein IgG) above the 90th percentile of levels observed among comparison subjects were associated with nonaffective psychosis (odds ratio=1.7, 95% CI=1.1-2.8). This association was not confounded by differences in maternal age, immigrant status, or mode of delivery. Similarly, gestational age at birth, ponderal index, and birth weight were not related to maternal levels of anti-gliadin IgG.Conclusions: High levels of anti-gliadin IgG in the maternal circulation are associated with an elevated risk for the development of a nonaffective psychosis in offspring. Research is needed to identify the mechanisms underlying this association in order to develop preventive strategies.