Surface-assisted self-assembly of 2D, DNA binary crystals
Surface-assisted self-assembly of 2D, DNA binary crystals
复制标题
二维 DNA 二元晶体的表面辅助自组装
DOI：
10.1039/d3nr01187a
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发表时间：
2023
期刊：
影响因子：
6.7
通讯作者：
Mao, Chengde
中科院分区：
文献类型：
--
作者：
Liu, Longfei;Mao, Dake;Li, Zhe;Zheng, Mengxi;He, Kai;Mao, Chengde
表面辅助、基于瓷砖的DNA自组装是构建大型二维(2D)纳米阵列的一种强有力的方法。为了进一步增加结构的复杂性，一种想法是将不同类型的瓷砖合并到一个组装系统中。然而，不同的瓷砖对固体表面的吸附强度不同。差异吸附使得不同浓度DNA碎片在固体表面的有效摩尔比难以控制，从而导致组装失败。在这里，我们提出了一种解决这个问题的方法，即在保持其结构不变的情况下，设计具有类似分子质量的瓷砖。作为演示，我们已经应用这一策略成功地用非常不同的瓷砖组装了二进制DNA 2D阵列。我们预计，这一策略也将促进其他复杂纳米结构的组装。
Surface-assisted, tile-based DNA self-assembly is a powerful method to construct large, two-dimensional (2D) nanoarrays. To further increase the structural complexity, one idea is to incorporate different types of tiles into one assembly system. However, different tiles have different adsorption strengths to the solid surface. The differential adsorptions make it difficult to control the effective molar ratio between different DNA tile concentrations on the solid surface, leading to assembly failure. Herein, we propose a solution to this problem by engineering the tiles with comparable molecular weights while maintaining their architectures. As a demonstration, we have applied this strategy to successfully assemble binary DNA 2D arrays out of very different tiles. We expect that this strategy would facilitate assembly of other complicated nanostructures as well.