Markers of inflammation and immune activation are associated with lung function in a multi-center cohort of persons with HIV.
Markers of inflammation and immune activation are associated with lung function in a multi-center cohort of persons with HIV.
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DOI：
10.1097/qad.0000000000002846
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发表时间：
2021-06-01
期刊：
影响因子：
--
通讯作者：
Huang L
中科院分区：
文献类型：
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作者：
Jan AK;Moore JV;Wang RJ;Mcging M;Farr CK;Moisi D;Hartman-Filson M;Kerruish R;Jeon D;Lewis E;Crothers K;Lederman MM;Hunt PW;Huang L
研究表明，艾滋病毒（PWH）感染者可能会增加慢性肺部疾病和肺功能异常的风险，这可能与免疫激活有关。我们测试了一组12种免疫活化和炎症生物标志物与肺量测定法和单次呼吸一氧化碳弥散量（DLco）的相关性。横断面观察性研究。参与者从两个美国研究中心的PWH I AM OLD队列中招募。检查生物标志物，并进行标准化肺量测定和DLco测试。我们使用多变量线性和逻辑回归，分别和联合检测了每种生物标志物与肺功能之间的相关性。在199名参与者中，FEV 1中位数正常（90%预测值），DLco中位数异常（69%预测值）。最常见的肺功能异常（57%）为FEV 1与用力肺活量比值正常，DLco异常≤80%预测值（iso↓DLco）。两种标志物（IL-6、hsCRP）与FEV1%预测值相关，而八种标志物（sCD 14、sCD 163、IP 10、sCD 27、IL-6、sTNFR-I、sTNFR-II、D-二聚体）与DLco%预测值相关。与肺功能正常和DLco正常的受试者相比，5种标志物（sCD 14、sCD 163、IP 10、sTNFR-I、sTNFR-II）与iso↓DLco相关。在PWH中，不同的免疫激活和炎症标志物与FEV1%预测值相关，而不是与DLco%预测值相关，并与iso↓DLco相关，代表慢性肺病可能的独特途径。确定这些炎症通路的合理驱动因素可能会澄清HIV感染中肺功能受损的潜在机制，并可能确定治疗途径。
Studies have shown that persons with HIV (PWH) may be at increased risk for chronic lung diseases and lung function abnormalities, which may be associated with immune activation. We tested the association of a panel of twelve immune activation and inflammation biomarkers with spirometry and single-breath diffusing capacity for carbon monoxide (DLco). Cross-sectional, observational study. Participants were enrolled from the I AM OLD cohort of PWH at two US sites. Biomarkers were examined and standardized spirometry and DLco testing were performed. We tested associations between each biomarker and lung function, examined individually and in combination, using multivariable linear and logistic regression. Among 199 participants, median FEV1 was normal (90% predicted) and median DLco was abnormal (69% predicted). The most common lung function abnormality (57%) was a normal FEV1 to forced vital capacity ratio with an abnormal DLco≤80% predicted (iso↓DLco). Two markers (IL-6, hsCRP) were associated with FEV1% predicted, whereas eight markers (sCD14, sCD163, IP10, sCD27, IL-6, sTNFR-I, sTNFR-II, D-dimer) were associated with DLco% predicted. Compared to those participants with normal spirometry and DLco, five markers (sCD14, sCD163, IP10, sTNFR-I, sTNFR-II) were associated with iso↓DLco. Among PWH, different markers of immune activation and inflammation are associated with FEV1% predicted than with DLco% predicted and with an iso↓DLco, representing possible unique pathways of chronic lung disease. Identifying plausible drivers of these inflammatory pathways may clarify mechanisms underlying impaired lung function in HIV infection and may identify therapeutic avenues.