Organic ion imaging using tandem mass spectrometry.
Organic ion imaging using tandem mass spectrometry.
复制标题
使用串联质谱法进行有机离子成像。
DOI：
10.1021/ac00041a023
复制
发表时间：
1992
影响因子：
7.4
通讯作者：
Markey,SP
中科院分区：
文献类型：
--
作者：
Todd,PJ;Short,RT;Grimm,CC;Holland,WM;Markey,SP
三重四极杆质谱仪已与广角二次离子微探针连接。即使在存在压倒性的同量异位干扰的情况下，该组合也可以获取确定目标有机分析物分布所需的数据。将仅由二次离子强度生成的显微照片与使用二次电离和串联质谱 (MS/MS) 生成的显微照片进行比较，既用于图像参考，又显示采用 MS/MS 时可以获得的图像质量的改进。使用甘油、KCl 和天冬酰胺在直径 1 厘米的铝靶上的不均匀混合物来证明仪器的选择性。该系统样品产生的二次离子包括从初级离子束注入的同量 133Cs+、41K+-甘油加合物和质子化天冬酰胺。
A trlple-quadrupole mass spectrometer has been Interfaced with a wide-angle secondary Ion microprobe. The combination permits acquisition of data necessary to determine the distribution of targeted organic analytes even In the presence of overwhelming Isobaric Interference. Micrographs generated from secondary Ion Intensity alone are compared to those generated using secondary Ionization with tandem mass spectrometry (MS/MS), both for Image reference and to show the Improvement In Image quality that can be attained when MS/MS Is employed. Inhomogeneous mixtures of glycerol, KCI, and asparagine on 1-cm-diameter aluminum targets were used to demonstrate the Instrument’sselectivity. Secondary Ions generated from samples of this system Include Isobaric 133Cs+ Implanted from the primary Ion beam, the 41K+-glycerol adduct, and protonated asparagine.