Evaluation of 31P metabolite differences in human cerebral gray and white matter.
Evaluation of 31P metabolite differences in human cerebral gray and white matter.
复制标题
评估人脑灰质和白质中 31P 代谢物的差异。
DOI：
10.1002/mrm.1910390303
复制
发表时间：
1998
影响因子：
3.3
通讯作者：
Hetherington,HP
中科院分区：
文献类型：
--
作者：
Mason,GF;Chu,WJ;Vaughan,JT;Ponder,SL;Twieg,DB;Adams,D;Hetherington,HP
31 P NMR通常用于研究健康和疾病中的大脑能量学。由于灵敏度限制，核磁共振测量通常在不含纯灰色或白色物质的体积中进行。为了准确评估脑代谢物水平的异常，有必要考虑灰质和白色物质中31 P代谢物正常水平的差异。在本研究中，分析了来自三维光谱图像采集的体素对组织类型的依赖性，以评估灰色和白色物质之间代谢物水平的差异。具体而言，灰质中磷酸肌酸（PCr）与γ-ATP和PCr与总31 P代谢物信号的比值显著较高，而灰质和白色物质之间的pH值和PCr与无机磷酸盐（P1）的比值差异不显著。因此，组织类型可以是一个重要的因素，考虑生物能量学的变化，通过31 P核磁共振光谱研究的大脑。
31P NMR is commonly used to study brain energetics in health and disease. Due to sensitivity constraints, the NMR measurements are typically made in volumes that do not contain pure gray or white matter. For accurate evaluation of abnormalities in brain metabolite levels, it is necessary to consider the differences in normal levels of31P metabolites in gray and white matter. In this study, voxels from a three‐dimensional spectroscopic image acquisition were analyzed for their dependence on tissue type to assess differences in metabolite levels between gray and white matter. Specifically, gray matter was found to have significantly higher ratios of phosphocreatine (PCr) to γ‐ATP and PCr to the total31P metabolite signal, whereas pH and the ratio of PCr to inorganic phosphate (P1) were found to differ insignificantly between gray and white matter. Thus, tissue type can be an important factor to consider for alterations in bioenergetics by31P NMR spectroscopic studies of the brain.