Specific memory within innate immune systems
Specific memory within innate immune systems
复制标题
DOI：
10.1016/j.it.2005.02.001
复制
发表时间：
2005-04-01
影响因子：
16.8
通讯作者：
Kurtz, J
中科院分区：
文献类型：
--
作者：
Kurtz, J
对免疫防御的研究由于对先天免疫的日益关注而大大丰富。这种类型的免疫仍然被认为缺乏特定记忆，主要是因为没有证据表明可以提供这种记忆的机制（如获得性免疫）。然而，最近的实验数据表明，无脊椎动物中存在特定的记忆现象：这些生物体被认为仅依赖于先天防御。在这里，我认为，一个明确的定义的术语“特异性”和“记忆”，再加上解剖的免疫防御的进化根源，告诉我们，先天免疫不应该是，也可能不是，一定没有特定的记忆。
Research into immune defense has been considerably enriched by the increasing focus on innate immunity. This type of immunity is still considered to lack specific memory, largely because there is no evidence of mechanisms that could provide such memory (such as acquired immunity). However, recent experimental data demonstrate specific memory phenomena in invertebrates: these organisms are thought to rely solely on innate defense. Here, I argue that a clear definition of the terms 'specificity' and 'memory', together with dissection of the evolutionary roots of immune defense, show us that innate immunity should not be, and is probably not, necessarily free of specific memory.