Modulation of suppressor-cell activity by cimetidine in patients with common variable hypogammaglobulinemia.
Modulation of suppressor-cell activity by cimetidine in patients with common variable hypogammaglobulinemia.
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西咪替丁对常见变异性低丙种球蛋白血症患者的抑制细胞活性的调节。
DOI：
10.1056/nejm198501243120402
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
M. Ballow
中科院分区：
文献类型：
--
作者：
W. White;M. Ballow
由于有证据表明西咪替丁（一种组胺 H2 受体拮抗剂）可能具有免疫调节作用，我们研究了该药物对 5 名患有常见变异性低丙种球蛋白血症的成年患者的作用。三名患者具有与全低丙种球蛋白血症相关的过度抑制细胞功能，而另外两名患者没有明显的 T 细胞缺陷。患者接受为期一个月的口服西咪替丁疗程（每天 1200 毫克，分四次服用）。随后，三名抑制细胞功能过度的患者的抑制活性显着降低，同时抑制细胞（T8+）数量也减少。这三者之一的体外免疫球蛋白分泌和血清免疫球蛋白浓度均显着升高，停药三个月后这种现象是可逆的，并且在重复西咪替丁治疗时可重现。服用西咪替丁时，没有过度抑制细胞活性的普通变异性低丙种球蛋白血症患者和十二指肠溃疡对照患者之间的免疫球蛋白分泌或抑制细胞活性没有差异。数据表明，H2 受体拮抗剂可能会降低抑制细胞的过度活性，并允许某些患有常见变异型低丙种球蛋白血症的患者产生内源性免疫球蛋白。
Because of evidence of a possible immunoregulatory role for cimetidine, an antagonist to histamine H2 receptors, we studied the effects of this drug in five adult patients with common variable hypogammaglobulinemia. Three patients had excessive suppressor-cell function associated with panhypogammaglobulinemia, whereas the other two had no apparent T-cell defects. The patients were given a one-month course of oral cimetidine (1200 mg daily in four divided doses). Subsequently, the three patients with excessive suppressor-cell function had a marked reduction in suppressor activity along with a decrease in the number of suppressor cells (T8+). One of these three had a marked rise in both in vitro immunoglobulin secretion and serum immunoglobulin concentrations, which was reversible after the drug was stopped for three months and reproducible when therapy with cimetidine was repeated. There was no difference in immunoglobulin secretion or suppressor-cell activity while taking cimetidine between the two patients with common variable hypogammaglobulinemia without excessive suppressor-cell activity and control patients with duodenal ulcers. The data suggest that H2-receptor antagonists may decrease excessive suppressor-cell activity and allow endogenous immunoglobulin production in some patients with common variable hypogammaglobulinemia.
TP5 治疗后成人普通变异性低丙种球蛋白血症的体外抑制细胞活性消失。
DOI：
--
发表时间：
1983
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
WilliamsJr,RC;Montano,JD;Bankhurst,AD
通讯作者：
Bankhurst,AD
与 T4 诱导 T 细胞功能丧失相关的免疫缺陷。
DOI：
10.1056/nejm198104023041403
发表时间：
1981
期刊：
The New England journal of medicine
影响因子：
--
作者：
Reinherz,EL;Geha,R;Wohl,ME;Morimoto,C;Rosen,FS;Schlossman,SF
通讯作者：
Schlossman,SF
DOI：
10.1016/0090-1229(83)90168-x
发表时间：
1983
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
Ershler,WB;Hacker,MP;Burroughs,BJ;Moore,AL;Myers,CF
通讯作者：
Myers,CF