Alternative transcription factor σB is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate
Alternative transcription factor σB is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate
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DOI：
10.1128/jb.182.23.6824-6826.2000
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发表时间：
2000-12-01
影响因子：
3.2
通讯作者：
Ziebuhr, W
中科院分区：
文献类型：
--
作者：
Rachid, S;Ohlsen, K;Ziebuhr, W
渗透压被发现诱导生物膜形成的金黄色葡萄球菌粘膜分离。细菌应激反应的全局调节因子，替代转录因子σ（B）的失活导致生物膜阴性表型和盐诱导的生物膜产生的损失。突变株与编码sigma（B）的表达质粒互补完全恢复了野生型表型。综合数据表明，西格玛（B）在S。金黄色葡萄球菌生物膜调节环境压力条件下。
Osmotic stress was found to induce biofilm formation in a Staphylococcus aureus mucosal isolate. Inactivation of a global regulator of the bacterial stress response, the alternative transcription factor sigma (B), resulted in a biofilm-negative phenotype and loss of salt-induced biofilm production. Complementation of the mutant strain with an expression plasmid encoding sigma (B) completely restored the wild-type phenotype. The combined data suggest a critical role of sigma (B) in S. aureus biofilm regulation under environmental stress conditions.