Regulation of lymphocytes redistribution via autonomic nervous activity during stochastic learning
Regulation of lymphocytes redistribution via autonomic nervous activity during stochastic learning
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DOI：
10.1016/j.bbi.2007.03.004
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发表时间：
2007-10-01
影响因子：
15.1
通讯作者：
Murashima, Seikou
中科院分区：
文献类型：
--
作者：
Kimura, Kenta;Ohira, Hideki;Murashima, Seikou
一些研究报道，急性心理应激任务会引起淋巴细胞亚群的重新分布，尤其是CD3-CD16+CD56+自然杀伤(NK)细胞。众所周知，淋巴细胞的再分配是基于主动或被动的情绪应对策略来调节的，这种情绪应对策略可以根据应激源的可控性而被诱发。可控性可以通过学习行为和结果之间的偶然性来逐渐评估。因此，淋巴细胞的重新分布可以通过学习偶然性来确定。为了检验这个问题，我们使用随机学习任务作为急性应激任务，并将20名健康参与者分成强化组或枷锁组。在这两组人之间，只有他们是否能了解到应急情况被操纵了。结果表明，强化组NK细胞数量变化规律不同，增强组NK细胞先显著升高，然后逐渐下降至基线水平，而枷锁组则表现为适度但持续的升高。NK细胞的这些变化模式与心血管参数的变化完全平行，但与儿茶酚胺的分泌无关。目前的结果表明，心血管和免疫反应性可以随着对急性应激源的适应进展而受到调节。(C)2007 Elsevier Inc.保留所有权利。
Several studies reported that redistribution of lymphocyte subsets, especially CD3-CD16+CD56+ natural killer (NK) cells, was elicited by acute psychological stress tasks. It is known that lymphocyte redistribution was regulated based on active or passive emotional coping strategies, which can be elicited dependent on controllability of a stressor. Controllability can be evaluated gradually by learning of a contingency between actions and outcomes. Therefore, lymphocyte redistribution can be determined by learning of the contingency. To examine this issue, we used a stochastic learning task as an acute stress task and divided twenty healthy participants into reinforcement or yoked groups. Between the two groups, only whether they could learn the contingency was manipulated. As a result, patterns of changes in the NK cell numbers differed between the groups; NK cells remarkably increased at first and then gradually decreased to the baseline in the reinforcement group while the yoked group showed a moderate but sustained increase of NK cells. These patterns of changes in the NK cells were completely parallel with changes of the cardiovascular parameters but not with secretion of catecholamines. The present results suggest that cardiovascular and immune reactivity can be modulated along with progresses of adaptation for an acute stressor. (C) 2007 Elsevier Inc. All rights reserved.