Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth
Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth
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DOI：
10.1046/j.1471-4159.2002.01146.x
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发表时间：
2002-09-01
影响因子：
4.7
通讯作者：
Braun, PE
中科院分区：
文献类型：
--
作者：
Kottis, V;Thibault, P;Braun, PE
从牛脑髓磷脂中纯化的蛋白质级分，由于其抑制神经突生长的能力而被称为髓鞘素，已被鉴定为主要由少突胶质细胞-髓磷脂糖蛋白（OMgp）组成。我们发现，它是一种有效的抑制剂，从大鼠小脑颗粒和海马细胞的轴突生长;从背根神经节外植体中观察到生长锥崩溃;从大鼠视网膜神经节神经元;从NG 108和PC 12细胞。通过不同的程序从小鼠和人髓磷脂纯化的OMgp在所有测试的生物测定中表现相同。
A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested.