FUNGAL ANTIGENS AS A SOURCE OF SENSITIZATION AND RESPIRATORY-DISEASE IN SCOTTISH MALTWORKERS
FUNGAL ANTIGENS AS A SOURCE OF SENSITIZATION AND RESPIRATORY-DISEASE IN SCOTTISH MALTWORKERS
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DOI：
10.1111/j.1365-2222.1977.tb01485.x
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发表时间：
1977-01-01
期刊：
影响因子：
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通讯作者：
GREENBERG, M
中科院分区：
文献类型：
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作者：
BLYTH, W;GRANT, IWB;GREENBERG, M
真菌学和血清学研究作为苏格兰麦芽工人呼吸道疾病调查的一部分。在574名工人的染色痰涂片中，70%显示存在高等植物细胞和/或菌丝体以及常见环境真菌的孢子。青霉属(90 699份痰培养物中真菌以根霉（48%）、曲茎根霉（48%）和酵母菌（53%）为主，56份麦芽中327份谷物、麦芽、秸秆和粉尘样品中真菌的比例分布相似。在711名男性中，57%的人血清学检查为真菌阳性，22%的人血清学检查为烟曲霉，20%的人血清学检查为曲霉。clavatus，A.黑尼日尔、草枝孢菌和匍匐根霉的分离率分别为16%和3%以上。在132名男性中，6%对P. cyclopium呈阳性。对40份血清的检测均未检测到抗链格孢菌、出芽短梗霉、白色念珠菌、白地霉、红酵母和绿色木霉抗原的沉淀抗体。5.2%有外源性过敏性肺泡炎症状的男性血清对棒曲霉菌丝抗原的反应性增加。该真菌是从21%的麦芽、7%的所有环境样本和8%的麦芽工人的唾液中培养出来的。
Mycological and serological studies were done as part of a survey of respiratory disease in Scottish maltworkers. Of stained sputum smears from 574 workers, 70% showed the presence of higher plant cells and/or mycelia, and the spores of common environmental fungi. Penicillium spp. (90%), Rhizopus stolonifer (48%) and yeasts (53%) were the dominant fungi in 699 sputum cultures, and showed a similar proportional distribution in 327 samples of grain, malt, culms and dusts from 56 maltings. Of 711 men, 57% were serologically positive for fungi, 22% for Aspergillus fumigatus, 20% for A. clavatus, 10% for A. niger, 16% for Cladosporium herbarum and over 3% for Rhizopus stolonifer. Of 132 men, 6% were positive for P. cyclopium. No precipitating antibodies to antigens from Alternaria tenuis, Aureobasidium pullulans, Candida albicans, Geotrichum candidum, Rhodotorula glutinis or Trichoderma viride were detected in tests of 40 sera. Sera from the 5.2% of men with symptoms of extrinsic allergic alveolitis showed increased reactivity to mycelial antigens from Aspergillus clavatus. The fungus was cultured from 21% of maltings, 7% of all environmental samples and from the sputa of 8% of maltworkers.