Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity.
Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity.
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肠道微生物群协同微进化与宿主体液免疫的选择
DOI：
10.3389/fmicb.2017.01243
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发表时间：
2017
影响因子：
5.2
通讯作者：
Meng H
中科院分区：
文献类型：
--
作者：
Yang L;Liu S;Ding J;Dai R;He C;Xu K;Honaker CF;Zhang Y;Siegel P;Meng H
为了探索肠道微生物群和宿主体液免疫系统之间的协同进化，我们使用鸡作为模式生物。宿主群体是两个系（HAS和LAS）和两个松弛亚系（HAR和LAR），这两个系是从一个共同的创始人那里发展起来的，该创始人经历了40代的绵羊红细胞（SRBC）抗体滴度的趋异选择。分析表明，宿主体液免疫的微进化有助于肠道微生物群在类群水平上的组成。松弛选择富集了一些与宿主免疫功能相反的微生物。特别是，瘤胃球菌科和颤螺旋菌丰富的高抗体松弛（HAR），并有助于降低抗体反应，而乳酸杆菌增加低抗体松弛（LAR），并提高抗体反应。微生物功能分析表明，改变涉及免疫系统和传染病相关的途径。我们的研究结果表明宿主微生物群的共同微进化关系以及肠道微生物影响宿主免疫力。
To explore coevolution between the gut microbiota and the humoral immune system of the host, we used chickens as the model organism. The host populations were two lines (HAS and LAS) developed from a common founder that had undergone 40 generations of divergent selection for antibody titers to sheep red blood cells (SRBC) and two relaxed sublines (HAR and LAR). Analysis revealed that microevolution of host humoral immunity contributed to the composition of gut microbiota at the taxa level. Relaxing selection enriched some microorganisms whose functions were opposite to host immunity. Particularly, Ruminococcaceae and Oscillospira enriched in high antibody relaxed (HAR) and contributed to reduction in antibody response, while Lactobacillus increased in low antibody relaxed (LAR) and elevated the antibody response. Microbial functional analysis showed that alterations were involved in pathways relating to the immune system and infectious diseases. Our findings demonstrated co-microevolution relationships of host-microbiota and that gut microorganisms influenced host immunity.