Demographic, lifestyle, and genetic determinants of circulating concentrations of 25-hydroxyvitamin D and vitamin D-binding protein in African American and European American women.
Demographic, lifestyle, and genetic determinants of circulating concentrations of 25-hydroxyvitamin D and vitamin D-binding protein in African American and European American women.
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DOI：
10.3945/ajcn.116.143248
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发表时间：
2017-06
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影响因子：
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通讯作者：
S. Yao;C. Hong;E. Bandera;Qianqian Zhu;Song Liu;T. Cheng;G. Zirpoli;S. Haddad;K. Lunetta;E. Ruiz-Narváez;S. McCann;M. Troester;L. Rosenberg;J. Palmer;A. Olshan;C. Ambrosone
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作者：
S. Yao;C. Hong;E. Bandera;Qianqian Zhu;Song Liu;T. Cheng;G. Zirpoli;S. Haddad;K. Lunetta;E. Ruiz-Narváez;S. McCann;M. Troester;L. Rosenberg;J. Palmer;A. Olshan;C. Ambrosone
背景：维生素D可能具有抗癌活性。非裔美国人（AAs）维生素D缺乏症的高患病率可能是导致非裔美国人（AAs）和欧裔美国人（EAs）之间癌症健康差异的一个促成因素。目的：我们比较了AA和EA女性中25（OH）D和维生素D结合蛋白（VDBP）的浓度，并调查了两个人群中维生素D生物标志物浓度的决定因素。设计：我们使用了来自非裔美国人乳腺癌流行病学和风险联盟的卡罗莱纳乳腺癌研究（CBCS）和妇女健康圈研究（WCHS）的909名AA和847名EA健康对照受试者的数据和生物标本。我们测量了所有参与者的血浆25（OH）D和VDBP浓度，并对AA女性的67个维生素D相关基因进行了基因分型。（平均值± SD：分别为14.2 ± 8.1和21.1 ± 11.5 ng/mL; P 0.05）在AA中，携带功能性单核苷酸多态性rs 4988235等位基因的AA女性，该等位基因先前与乳糖酶表达和乳糖耐受性相关，结论：AA妇女的总25（OH）D浓度低于EA妇女，但两组的VDBP浓度相似，表明AA中游离25（OH）D浓度较低。虽然人口统计学和生活方式的25（OH）D浓度的决定因素是相似的两组之间，遗传决定因素可能是种族特异性。需要对AA进行更大规模的研究，以充分阐明AA人群中维生素D浓度低的潜在决定因素。
Background: Vitamin D may have anticancer activities. The high prevalence of vitamin D deficiency in African Americans (AAs) may be a contributing factor to the cancer health disparities between AAs and European Americans (EAs).Objectives: We compared concentrations of 25(OH)D and vitamin D-binding protein (VDBP) in AA and EA women and investigated determinants of the vitamin D-biomarker concentrations in both populations.Design: We used data and biospecimens from 909 AA and 847 EA healthy control subjects from the Carolina Breast Cancer Study (CBCS) and the Women's Circle of Health Study (WCHS) in the African American Breast Cancer Epidemiology and Risk Consortium. We measured plasma 25(OH)D and VDBP concentrations in all participants and genotyped 67 vitamin D-related genes in AA women only.Results: AA women had lower 25(OH)D concentrations than did EA women (mean ± SD: 14.2 ± 8.1 compared with 21.1 ± 11.5 ng/mL, respectively; P 0.05) in AAs, AA women who carried the allele of a functional single nucleotide polymorphism rs4988235, which has been previously associated with lactase expression and lactose tolerance, had higher dietary vitamin D intake and higher measured 25(OH)D concentrations.Conclusions: AA women have lower concentrations of total 25(OH)D than EA women do, but both groups have similar VDBP concentrations, suggesting that there are lower concentrations of free 25(OH)D in AAs. Although demographic and lifestyle determinants of 25(OH)D concentrations are similar between the 2 groups, genetic determinants may be ethnicity specific. Larger studies in AAs will be needed to fully elucidate the underlying determinants of low vitamin D concentrations in AA populations.