Acquired hemophilia in a patient with systemic lupus erythematosus: a case report and literature review
Acquired hemophilia in a patient with systemic lupus erythematosus: a case report and literature review
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系统性红斑狼疮患者获得性血友病一例报告及文献复习
DOI：
10.3109/s10165-008-0084-6
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发表时间：
2008
影响因子：
2.2
通讯作者：
H. Nakashima
中科院分区：
文献类型：
--
作者：
M. Akahoshi;K. Aizawa;S. Nagano;H. Inoue;A. Sadanaga;Y. Arinobu;H. Niiro;H. Nakashima
我们报告一位38岁的女性系统性红斑狼疮(SLE)患者，她因凝血因子VIII(FVIII)抑制剂引起的获得性血友病。她表现为自发性出血症状，如瘀斑和血尿。实验室结果显示激活的部分凝血活酶时间单独延长，FVIII活性降低，FVIII抑制剂效价高。她在口服强的松龙和环孢素A的同时配合类固醇和环磷酰胺的冲击治疗获得成功。
We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) who developed acquired hemophilia caused by factor VIII (FVIII) inhibitors. She manifested spontaneous bleeding symptoms such as ecchymoses and hematuria. Laboratory findings showed an isolated prolongation of the activated partial thromboplastin time, reduced FVIII activity, and a high titer of FVIII inhibitors. She was successfully treated with oral predonisolone and cyclosporine in combination with steroid and cyclophosphamide pulse therapy.
获得性凝血抑制剂的静脉注射免疫球蛋白治疗。
DOI：
--
发表时间：
2007
期刊：
International Journal of Hematology 85
影响因子：
--
作者：
Yamamoto K;Takamatsu J;Saito H.
通讯作者：
Saito H.