Influence of estrogen and osteogenia/osteoporosis on clinical periodontitis in postmenopausal women
Influence of estrogen and osteogenia/osteoporosis on clinical periodontitis in postmenopausal women
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DOI：
10.1902/jop.1999.70.8.823
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发表时间：
1999-08-01
影响因子：
4.3
通讯作者：
Mattson, JS
中科院分区：
文献类型：
--
作者：
Reinhardt, RA;Payne, JB;Mattson, JS
背景资料：在西方社会，超过三分之一的65岁以上的女性人口患有骨质疏松症的体征和症状，这是一种以低骨量为特征的疾病。雌激素缺乏是女性骨质疏松症的主要致病因素。雌激素缺乏和骨质减少/骨质疏松对牙周炎的影响尚不清楚，部分原因是缺乏纵向研究评估牙龈炎症和牙周炎进展的临床体征。本调查的目的是前瞻性地分析血清雌二醇水平和骨质减少/骨质疏松症对牙周病的常见临床测量的影响超过2-yearperiod.Methods：59中度/晚期成人牙周炎患者和16名非牙周炎受试者，所有在5年内绝经后在基线，完成了这项研究。每年通过I-125放射免疫测定法测定血清雌二醇水平（E-2），并通过腰椎双能X线吸收测定法测定骨质减少/骨质疏松。每6个月对牙周炎患者进行一次后牙邻面临床测量，包括探诊器可检测的龈上菌斑、探诊出血（BOP）和相对临床附着水平（RCAL）。基线探测深度，吸烟史，和人口学数据也被collected.Results：数据表明，基线人口统计学测量和腰椎骨密度（BMD）之间E-2-缺乏和E-2-充足的科目没有不同。牙周炎患者的吸烟活动（吸烟包/天，吸烟年数）更高（P=0.0001）。E-2充足的牙周炎受试者有更高的龈上菌斑频率，而不增加牙龈炎症。无论是牙周炎组还是非牙周炎组，E-2水平均不影响RCAL丧失部位的百分比，但当评估非吸烟骨质减少/骨质疏松性牙周炎患者时，E-2缺乏的受试者有更多的BOP（43.8%对24.4%，P
Background: In Western societies, more than one-third of the female population above age 65 suffers from signs and symptoms of osteoporosis, a disorder characterized by low bone mass. Estrogen deficiency is the dominant pathogenic factor for osteoporosis in women. The impact of estrogen deficiency and osteopenia/osteoporosis on periodontitis is unclear, partially due to the lack of longitudinal studies evaluating clinical signs of gingival inflammation and periodontitis progression. The purpose of this investigation was to analyze prospectively the influence of serum estradiol levels and osteopenia/osteoporosis on common clinical measurements of periodontal disease over a 2-year period.Methods: Fifty-nine moderate/advanced adult periodontitis patients and 16 non-periodontitis subjects, all within 5 years after menopause at baseline, completed the study. Serum estradiol levels (E-2) were measured yearly by I-125 radioimmunoassay, and osteopenia/osteoporosis was determined by dual energy x-ray absorptiometry of the lumbar spine. Posterior interproximal clinical measurements were obtained every 6 months for the periodontitis patients, including explorer-detectable supragingival plaque, bleeding on probing (BOP) and relative clinical attachment level (RCAL). Baseline probing depths, smoking history, and demographic data also were collected.Results: Data indicated that baseline demographic measurements and bone mineral density (BMD) of the lumbar spine were not different between E-2-deficient and E-2-sufficient subjects. Smoking activity (packs smoked/day, years smoked) was higher in periodontitis patients (P=0.0001). E-2-sufficient periodontitis subjects had a higher frequency of supragingival plaque without increasing gingival inflammation. E-2 status did not influence the percentage of sites losing RCAL for either periodontitis or non-periodontitis groups, but when non-smoking osteopenic/osteoporotic periodontitis patients were evaluated, E-2-deficient subjects had more BOP (43.8% versus 24.4%, P