Neurofunctional differences associated with arithmetic processing in turner syndrome
Neurofunctional differences associated with arithmetic processing in turner syndrome
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DOI：
10.1093/cercor/bhj028
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发表时间：
2006-06-01
期刊：
影响因子：
3.7
通讯作者：
Reiss, Allan L.
中科院分区：
文献类型：
--
作者：
Kesler, Shelli R.;Menon, Vinod;Reiss, Allan L.
特纳综合征（TS）是一种神经遗传疾病，其特征是表现型女性缺少一条X染色体。患有TS的人在数学方面有受损的风险。我们研究了TS中算术处理的神经机制。15名TS患者和15名年龄匹配的正常发育对照者在执行简单（双操作数）和困难（三操作数）的算术处理任务时使用功能性MRI扫描。在数学任务中，两组人都激活了与算术处理有关的额顶叶区域。与对照组相比，TS组在更简单的双操作数学任务中在额叶和顶叶区域调动了额外的神经资源。在难度更高的三操作任务中，TS患者在额叶、顶叶和皮层下区域的激活明显低于对照组。然而，TS组在两项数学任务上的表现与对照组相当。与对照组相比，患有TS的个体在算术任务中表现出额顶叶区域的激活差异。他们必须在相对简单的任务中调动额外的大脑区域，并且与对照组相比，在任务难度增加时表现出潜在的低效反应。
Turner syndrome (TS) is a neurogenetic disorder characterized by the absence of one X chromosome in a phenotypic female. Individuals with TS are at risk for impairments in mathematics. We investigated the neural mechanisms underlying arithmetic processing in TS. Fifteen subjects with TS and 15 age-matched typically developing controls were scanned using functional MRI while they performed easy (two-operand) and difficult (three-operand) versions of an arithmetic processing task. Both groups activated fronto-parietal regions involved in arithmetic processing during the math tasks. Compared with controls, the TS group recruited additional neural resources in frontal and parietal regions during the easier, two-operand math task. During the more difficult three-operand task, individuals with TS demonstrated significantly less activation in frontal, parietal and subcortical regions than controls. However, the TS group's performance on both math tasks was comparable to controls. Individuals with TS demonstrate activation differences in fronto-parietal areas during arithmetic tasks compared with controls. They must recruit additional brain regions during a relatively easy task and demonstrate a potentially inefficient response to increased task difficulty compared with controls.