RECENT DEVELOPMENTS IN ELECTROCHEMICAL SENSORS FOR THE DETECTION OF NEUROTRANSMITTERS FOR APPLICATIONS IN BIOMEDICINE.
RECENT DEVELOPMENTS IN ELECTROCHEMICAL SENSORS FOR THE DETECTION OF NEUROTRANSMITTERS FOR APPLICATIONS IN BIOMEDICINE.
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DOI：
10.1080/00032719.2014.976867
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发表时间：
2015-05-03
影响因子：
2
通讯作者：
Andreescu S
中科院分区：
文献类型：
--
作者：
Özel RE;Hayat A;Andreescu S
神经递质是重要的生物分子，对许多神经生理过程包括记忆、认知和行为状态是必需的。准确检测神经递质的分析方法的发展在神经学和生物学研究中具有重要意义。专门设计的微电极或微生物传感器已经证明了具有高空间分辨率的快速，实时测量的潜力。这种装置可以促进对神经递质的作用和作用机制的研究，并可以在生物医学中找到潜在的用途。本文综述了近年来电化学传感器在小分子神经递质检测中的研究和应用现状。测量的挑战和电分析方法的机会，以促进研究和理解的神经递质在各种生物模型和疾病的条件进行了讨论。
Neurotransmitters are important biological molecules that are essential to many neurophysiological processes including memory, cognition, and behavioral states. The development of analytical methodologies to accurately detect neurotransmitters is of great importance in neurological and biological research. Specifically designed microelectrodes or microbiosensors have demonstrated potential for rapid, real-time measurements with high spatial resolution. Such devices can facilitate study of the role and mechanism of action of neurotransmitters and can find potential uses in biomedicine. This paper reviews the current status and recent advances in the development and application of electrochemical sensors for the detection of small-molecule neurotransmitters. Measurement challenges and opportunities of electroanalytical methods to advance study and understanding of neurotransmitters in various biological models and disease conditions are discussed.