Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride.
Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride.
复制标题
氯化汞诱导布朗挪威大鼠抗肾小球基底膜抗体。
DOI：
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发表时间：
1977
影响因子：
4.6
通讯作者：
P. Druet
中科院分区：
文献类型：
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作者：
C. Sapin;E. Druet;P. Druet
抗肾小球基底膜（GBM）抗体诱导的Brown-Norway大鼠氯化汞。由于免疫荧光线性模式，怀疑存在抗GBM抗体。这是因为从肾脏洗脱的抗体和循环IgG具有抗肾小球基底膜活性。经氯化汞修饰的肾小球基底膜抗原可能是导致这种抗体出现的原因。在相同的实验条件下，在远系繁殖的Wistar大鼠中发生免疫复合物型肾小球肾炎的先前证明表明存在这种类型的免疫应答的遗传控制。
Anti-glomerular basement membrane (GBM) antibodies were induced in the Brown-Norway rat by mercuric chloride. The existence of anti-GBM antibodies was suspected because of the immunofluorescent linear pattern. It was proved because eluted antibodies from kidneys and circulating IgG had an anti-glomerular basement membrane activity. A glomerular basement membrane antigen modified by HgCl2 is probably responsible for the appearance of such antibodies. The previous demonstration of the occurrence of an immun complex type glomerulonephitis, in outbred Wistar rats, under the same experimental conditions, suggests the existence of a genetic control for this type of immune response.