In vivo sodium concentration continuously monitored with fluorescent sensors
In vivo sodium concentration continuously monitored with fluorescent sensors
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DOI：
10.1039/c0ib00020e
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发表时间：
2011-01-01
影响因子：
2.5
通讯作者：
Clark, Heather
中科院分区：
文献类型：
--
作者：
Dubach, J. Matthew;Lim, Edward;Clark, Heather
钠平衡对维持正常的生理功能至关重要。不平衡可能发生在各种疾病中，在某些外科手术或严格的运动期间。目前还没有一种方法可以连续监测可能易患低钠血症的患者的钠浓度。我们的方法是设计能够测量钠浓度的生理波动的钠特异性荧光传感器。传感器是亚微米塑化聚合物颗粒，含有钠识别成分，涂有生物相容性聚乙二醇。在这里，传感器被带到盐水中，并通过简单的注射放置在小鼠皮肤的皮下区域。使用整个动物成像仪真实的实时监测荧光以跟踪钠浓度的变化。这项技术可用于监测某些疾病状态，或在运动期间警告危险的低钠水平。
Sodium balance is vital to maintaining normal physiological function. Imbalances can occur in a variety of diseases, during certain surgical operations or during rigorous exercise. There is currently no method to continuously monitor sodium concentration in patients who may be susceptible to hyponatremia. Our approach was to design sodium specific fluorescent sensors capable of measuring physiological fluctuations in sodium concentration. The sensors are submicron plasticized polymer particles containing sodium recognition components that are coated with biocompatible poly(ethylene) glycol. Here, the sensors were brought up in saline and placed in the subcutaneous area of the skin of mice by simple injection. The fluorescence was monitored in real time using a whole animal imager to track changes in sodium concentrations. This technology could be used to monitor certain disease states or warn against dangerously low levels of sodium during exercise.