Changes of White Matter Diffusion Anisotropy in Response to a 6-Week iPad Application-Based Occupational Therapy Intervention in Children with Surgically Treated Hydrocephalus: A Pilot Study.
Changes of White Matter Diffusion Anisotropy in Response to a 6-Week iPad Application-Based Occupational Therapy Intervention in Children with Surgically Treated Hydrocephalus: A Pilot Study.
复制标题
对接受手术治疗的脑积水儿童进行为期 6 周的基于 iPad 应用的职业治疗干预后白质扩散各向异性的变化：一项试点研究。
DOI：
10.1055/s-0036-1584938
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发表时间：
2016
期刊：
影响因子：
1.4
通讯作者：
Simpso
中科院分区：
文献类型：
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作者：
Yuan,Weihong;Harpster,Karen;Jones,BlaiseV;Shimony,JoshuaS;McKinstry,RobertC;Weckherlin,Nicole;Powell,StephanieS;Barnard,Holly;Engsberg,Jack;Kadis,DarrenS;Dodd,Jonathan;Altaye,Mekibib;Limbrick,DavidD;Holland,ScottK;Simpso
我们的目的是（1）测试弥散张量成像（DTI）是否可以检测手术治疗脑积水（HCP）儿童在6周iPad应用程序为基础的职业治疗（OT）干预后潜在的白色（WM）变化;（2）探索WM变化与性能结果之间的关联。（年龄范围：6.05-9.10岁）手术治疗的HCP完成了针对HCP儿童长期缺陷常见领域的基于iPad的强化OT干预。干预措施包括在OT诊所每周6次，补充以家庭为基础的计划（1小时/天，4天/周）。观察治疗后，广泛的WM区域的各向异性分数（FA）显著增加和/或径向扩散率显著降低。所有被试的知觉推理指数（PRI，韦氏简明智力量表：第二版，PRI增益= 14.20 ± 7.56，p = 0.014）均有所提高。PRI增加与内囊右后肢和右外囊FA增加之间存在显著正相关（bothp< 0.05）。
ObjectiveOur aims were (1) to test whether diffusion tensor imaging (DTI) could detect underlying white matter (WM) changes after a 6-week iPad application-based occupational therapy (OT) intervention in children with surgically treated hydrocephalus (HCP); and (2) to explore the association between WM changes and performance outcomes.MethodsFive children (age range: 6.05–9.10 years) with surgically treated HCP completed an intensive iPad-based OT intervention targeting common domains of long-term deficits in children with HCP. The intervention included 6 weekly sessions in an OT clinic supplementing home-based program (1 hour/day, 4 days/week). DTI and neuropsychological assessments were performed before and after the intervention.ObservationAfter the therapy, significant increases in fractional anisotropy (FA) and/or decreases in radial diffusivity were found in extensive WM areas. All participants demonstrated an increased perceptual reasoning index (PRI, Wechsler Abbreviated Scale of Intelligence: 2nd edition, PRI gains = 14.20 ± 7.56,p= 0.014). A significant positive correlation was found between PRI increase and the increase of FA in the right posterior limb of the internal capsule and the right external capsule (bothp< 0.05).ConclusionThis study provides initial evidence of DTI's sensitivity to detect subtle WM changes associated with performance improvements in response to a 6-week OT intervention in children with HCP.