An alternative synthesis of [11C]raclopride for routine use
An alternative synthesis of [11C]raclopride for routine use
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DOI：
10.1007/bf03164862
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发表时间：
1999-06-01
影响因子：
2.6
通讯作者：
Senda, M
中科院分区：
文献类型：
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作者：
Ishiwata, K;Ishii, S;Senda, M
[C-11]丙氯pride的标准合成方法需要大量的去甲基前体。我们将少量去甲基衍生物（0.3-0.5 mg）与[C-11]碘化甲基化，在含有NaH的DMF溶液中制备[C-11]氯氯pride，以[C-11]碘化甲基为基础，衰变校正的放射化学产率为11-14%，比活性为48 TBq/mmol，从EOB中提取25 min。该反应重现性好，可靠。
The standard method of [C-11]raclopride synthesis requires a large amount of its desmethyl precursor. We prepared [C-11]raclopride by methylation of a small amount of desmethyl derivative (0.3-0.5 mg) with [C-11]methyl iodide in a DMF solution containing NaH, with a decay-corrected radiochemical yield of 11-14% based on [C-11]methyl iodide and with a specific activity of 48 TBq/mmol for 25 min from EOB. The reaction was reproducible and reliable.