Hyperostosis associated with meningioma of the cranial base: Secondary changes or tumor invasion
Hyperostosis associated with meningioma of the cranial base: Secondary changes or tumor invasion
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DOI：
10.1097/00006123-199904000-00028
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发表时间：
1999-04-01
期刊：
影响因子：
4.8
通讯作者：
Buechner, D
中科院分区：
文献类型：
--
作者：
Pieper, DR;Al-Mefty, O;Buechner, D
目的：与颅内脑膜瘤相关的骨质增生是一个很好的描述。这些骨改变的原因、治疗和预后一直是一个有争议的问题。有些作者认为，骨肥厚是继发于肿瘤的形成，并不构成肿瘤侵入骨。确定这一点对这些患者的治疗有直接影响，特别是关于手术考虑。为了更彻底地评估这个问题，一项研究相关的形态学的放射学是necessary.METHODS：在这项研究中，51例患者进行切除脑膜瘤涉及颅底。使用磁共振成像和/或计算机断层扫描进行术前影像学评价，并确定骨质增生区域。在切除肿瘤，从这些骨质增生区域的活检组织学评价的存在或不存在的肿瘤侵袭bone.RESULTS：术前神经放射学评估确定了26例放射学证据的骨质增生。切除骨的组织学检查显示35例患者的肿瘤浸润，包括26例患者中25例的放射学确定的骨质增生区域。中颅窝底是一个特定的区域，术前评估相关hyperostosis.CONCLUSION的敏感性低：这些结果表明，骨质增生与脑膜瘤涉及颅底是由肿瘤侵犯骨组织学。
OBJECTIVE: Hyperostosis associated with intracranial meningiomas is a well-described entity. The cause, management, and prognosis of these bony changes have long been a point of controversy. Some authors have postulated that hyperostotic changes are secondary to the formation of the tumor and do not constitute invasion of the tumor into the bone. Determining this point has direct implications in the treatment of these patients, especially regarding surgical considerations. To more thoroughly evaluate this question, a study correlating the morphology to the radiology is necessary.METHODS: In this study, 51 patients underwent resection for meningiomas involving the cranial base. Preoperative radiographic evaluation using magnetic resonance imaging and/or computed tomography was performed, and areas of hyperostosis were identified. During the resection of the tumor, biopsies from these hyperostotic regions were sent for histological evaluation regarding the presence or absence of tumor invasion of the bone.RESULTS: Preoperative neuroradiological assessment identified 26 patients with radiographic evidence of hyperostosis. Histological examination of the resected bone showed tumor invasion in 35 patients, including the area of radiographically identified hyperostosis in 25 of the 26 patients. The floor of the middle fossa was a specific area of low sensitivity for preoperative assessment of associated hyperostosis.CONCLUSION: These results indicate that hyperostosis associated with meningiomas involving the cranial base are caused by tumor invasion of the bone histologically.