Mycobacterium tuberculosis-secreted protein antigens: immunogenicity in baboons.
Mycobacterium tuberculosis-secreted protein antigens: immunogenicity in baboons.
复制标题
结核分枝杆菌分泌的蛋白质抗原：狒狒的免疫原性。
DOI：
10.1023/a:1017215720949
复制
发表时间：
2000
影响因子：
9.1
通讯作者：
Attanasio,R
中科院分区：
文献类型：
--
作者：
Pehler,K;Brasky,KM;Butler,TM;Attanasio,R
The effective control of tuberculosis (TB) requires the development of improved vaccines. It is now well established thatMycobacterium tuberculosis-secreted antigens represent promising candidates to be included in subunit vaccine preparations. It also is accepted that studies in nonhuman primate models will be required to further develop these vaccine preparations. As a necessary step in this direction, we have assessed the immunogenicity ofM. tuberculosis-secreted antigens in baboons. Animals received a total of three intramuscular injections consisting ofM. tuberculosisculture filtrate proteins resuspended in an adjuvant formulation (MPL-SE) and were tested for development of specific antibody and cellular responses. All animals produced antibody and cellular proliferative responses in the absence of detectable delayed-type hypersensitivity reactions. Production of γ-interferon following stimulation of peripheral blood lymphocytes with culture filtrate proteins was either absent or present at low levels. Results from this study show that, althoughM. tuberculosis-secreted protein antigens are relatively safe and immunogenic in baboons, alternative immunization approaches must be identified for the induction of T-helper type 1 responses.
