The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy.
The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy.
复制标题
DOI：
10.1586/17474124.2.1.125
复制
发表时间：
2008-02-01
影响因子：
3.9
通讯作者：
Arber, Nadir
中科院分区：
文献类型：
--
作者：
Sagiv, Eyal;Arber, Nadir
CD 24在20世纪80年代初首次被描述，并且仅归因于分散的出版物，被称为造血中的细胞表面分子。近年来，越来越多的研究表明，CD 24在细胞与细胞的相互作用以及增殖和粘附的调节中发挥作用。CD 24似乎在多种人类癌症中高度表达，并通过与血小板（P）-选择素L1结合和通过引发迄今未知的细胞内信号途径而促进肿瘤生长和转移脱落的加速。因此，抗CD 24单克隆抗体作为一种有前途的癌症治疗，如在胃肠道癌症的背景下所示。最近的文章还将CD 24表达与“肿瘤干细胞”的鉴定相关联。
CD24 was first described in the early 1980s and only attributed to scattered publications, referred to as a cell surface molecule in hematopoiesis. Recently, studies are accumulating to show that CD24 conveys a function in cell-to-cell interaction and regulation of proliferation and adhesion. CD24 appears to be highly expressed in a large variety of human cancers and to contribute to the acceleration of tumor growth and metastases shedding by binding to platelet (P)-selectin, L1 and by evoking--to date unknown--intracellular signal pathways. Anti-CD24 monoclonal antibodies thus act as a promising cancer treatment as was shown in the setting of gastrointestinal cancers. Recent articles also correlate CD24 expression with the identification of 'tumor stem cells'.