Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm
Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm
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DOI：
10.1002/jmri.20496
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发表时间：
2006-03-01
影响因子：
4.4
通讯作者：
Arai, AE
中科院分区：
文献类型：
--
作者：
Hsu, LY;Natanzon, A;Arai, AE
目的：建立一种计算机算法来测量钆增强磁共振（MR）成像中的心肌梗死面积，并通过犬的组织病理学参考来验证该方法。材料与方法：对11只心肌梗死（MI）犬进行延迟增强磁共振成像（MR）检测。通过基于自动特征分析和联合阈值（FACT）的计算机算法测量体内和离体图像的梗死面积。为了进行比较，研究了人工绘制的梗死面积和简单的强度阈值（基于两个标准差[2SD]和半最大值时的全宽度[FWHM]）。结果：FACT算法测量的体内和离体MR梗死面积与TTC相关性良好（R = 0.95 ~ 0.97）， Bland Altman分析无显著偏差（P =无统计学意义）。尽管存在相似的相关关系（R = 0.91-0.97），但与TTC相比，人工绘制术高估了体内MR梗死面积的5.4%（相当于心肌梗死面积的55.1%）（P < 0.001）。通过简单的强度阈值测量梗死面积的准确性低于所提出的算法（P < 0.001和P = 0.007）。结论：FACT算法在体内和离体延迟增强MR成像中准确测量心肌梗死大小。FACT算法也比人工轮廓和简单的强度阈值方法更准确。
Purpose: To develop a computer algorithm to measure myocardial infarct size in gadolinium-enhanced magnetic resonance (MR) imaging and to validate this method using a canine histopathological reference.Materials and Methods: Delayed enhancement MR was performed in 11 dogs with myocardial infarction (MI) determined by triphenyltetrazolium chloride (TTC). Infarct size on in vivo and ex vivo images was measured by a computer algorithm based on automated feature analysis and combined thresholding (FACT). For comparison, infarct size by human manual contouring and simple intensity thresholding (based on two standard deviation [2SD] and full width at half maximum [FWHM]) were studied.Results: Both in vivo and ex vivo MR infarct size measured by the FACT algorithm correlated well with TTC (R = 0.95-0.97) and showed no significant bias on Bland Altman analysis (P = not significant). Despite similar cor-relations (R = 0.91-0.97), human manual contouring overestimated in vivo MR infarct size by 5.4% of the left ventricular [LV] area (equivalent to 55.1% of the MI area) vs. TTC (P < 0.001). Infarct size measured by simple intensity thresholdings was less accurate than the proposed algorithm (P < 0.001 and P = 0.007).Conclusion: The FACT algorithm accurately measured MI size on delayed enhancement MR imaging in vivo and ex vivo. The FACT algorithm was also more accurate than human manual contouring and simple intensity thresholding approaches.